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Assessment of ovarian reserve decline and lifestyle-related disease risk caused by cumulative smoking volume of active smoking and passive smoking

Research Project

Project/Area Number 15K11689
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Lifelong developmental nursing
Research InstitutionKansai Medical University (2018)
Morinomiya University of Medical Sciences (2015-2017)

Principal Investigator

SAKAI Hiroko  関西医科大学, 看護学部, 教授 (90434927)

Co-Investigator(Kenkyū-buntansha) 大橋 一友  大阪大学, 医学系研究科, 教授 (30203897)
橋本 富子  森ノ宮医療大学, 保健医療学部, 教授 (70701861)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords更年期女性 / 受動喫煙 / 更年期症状 / 抑うつ症状 / 能動喫煙 / 生活習慣病 / 卵巣機能 / 更年期 / 更年期周辺期女性
Outline of Final Research Achievements

The present study was performed for women with mean age of 48.32±3.17 years born during a period from the 1960s to 1970s when the smoking rate of Japanese men exceeded 80% and there was exposure second-hand smoke for long period of years. The results of a self-administered questionnaire survey demonstrate that not only smoking, but also exposure to passive smoking has a risk to exacerbate menopause symptom and severity of depression. It was also shown that passive smoking could be a risk to exacerbate menopause symptom not only by status of smoking and exposure to passive smoking evaluated by urinary nicotine level, but also by exposure evaluation for subjects of estimated exposure accumulation amount over their whole life to date based on a semi-quantified formula as well as the results of statistical approach adjusted for the impact of multiple factors.

Academic Significance and Societal Importance of the Research Achievements

本研究は能動喫煙と受動喫煙が及ぼす更年期女性の健康への影響を評価した。卵巣予備能低下を早めるリスクの特定には至らなかったが、能動喫煙だけではなく受動喫煙が更年期症状と抑うつを悪化させ生活習慣病のリスクとなる示唆を得た。女性の健康寿命の延伸とQOLの向上のために、生涯にわたる女性の能動・受動喫煙の予防的取り組みが重要である。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2015

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] 喫煙が及ぼす卵巣機能・卵管・子宮への影響2018

    • Author(s)
      酒井ひろ子
    • Journal Title

      日本ウーマンズヘルス学会

      Volume: 17 Pages: 37-42

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 喫煙が及ぼす卵巣機能・卵管・子宮への影響2018

    • Author(s)
      酒井ひろ子
    • Journal Title

      日本ウーマンズヘルス学会誌

      Volume: 17

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] ニコチン薬理作用・ニコチン依存度の性差~女性の禁煙対策の課題~2015

    • Author(s)
      酒井ひろ子
    • Journal Title

      日本ウーマンズヘルス学会誌

      Volume: 14 Pages: 1-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 更年期周辺期にある女性の生活習慣病と更年期症状との関連検討2018

    • Author(s)
      外村晴美 酒井ひろ子
    • Organizer
      第30回近畿・北陸地方会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 更年期周辺期にある女性の生活習慣病と更年期症状との関連検討2017

    • Author(s)
      外村晴美 奥川裕子 神埼真姫 酒井ひろ子
    • Organizer
      日本看護研究学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 生殖期年齢にある女性の受動喫煙暴露歴と抑うつとの関連検討2015

    • Author(s)
      酒井ひろ子 大橋一友
    • Organizer
      日本禁煙学会第9回学術集会
    • Place of Presentation
      市民会館崇城大学ホール(熊本市民会館) 国際交流会館
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 20代女性の再煙と喫煙状況、日常生活、月経周期関連症、禁煙開始時期との関連2015

    • Author(s)
      酒井ひろ子 大橋一友
    • Organizer
      日本禁煙学会第9回学術集会
    • Place of Presentation
      市民会館崇城大学ホール(熊本市民会館) 国際交流会館
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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