Pathway analysis to elucidate mechanism of muscle atrophy under microgravity and development of causal therapy
| Project/Area Number |
15K11917
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
宇宙生命科学
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| Research Institution | Kyoto University |
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Principal Investigator |
SATO Fuminori 京都大学, ウイルス・再生医科学研究所, 特定助教 (10588263)
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| Co-Investigator(Kenkyū-buntansha) |
瀬原 淳子 京都大学, ウイルス・再生医科学研究所, 教授 (60209038)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAKAMI Koichi 国立遺伝学研究所, 教授 (70195048)
SUZUKI Yutaka 東京大学, 新領域創成科学研究科, 教授 (40323646)
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| Research Collaborator |
UCHIDA Satoko
KATO Mitsuyasu
TANIGAKI Fumiaki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ゼブラフィッシュ / 骨格筋 / トランスクリプトーム / 微重力環境 / 宇宙滞在 / 骨格筋萎縮 / 筋萎縮 / トランスクリプトーム解析 / 放射線 / myostatin |
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| Outline of Final Research Achievements |
We conducted long-term space stay experiments using zebrafish which is an aquatic animal, and analyzed muscle atrophy in microgravity environment. However, it was unknown whether the expression changed genes confirmed by this long-term space staying experiment were microgravity dependent or other factors such as cosmic radiation. Therefore, a low dose γ ray irradiation experiment simulating long-term space stay was carried out.As a result, it was suggested that genes which were changed in expression level by space stay include genes which were changed in expression level by radiation.Due to the need for more detailed analysis, we conducted a short-term space stay experiment of zebrafish using an artificial 1 G environment in the ISS on orbit as a control.
By integrally analyzing these results, it is thought that it becomes possible to identify genes which is responsible to the microgravity environment
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Report
(4 results)
Research Products
(31 results)
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[Presentation] What can we learn by exploring the interstitial space of skeletal muscle during development and regeneration2015
Author(s)
Sato F, Nishimura D, Hori S, Arai H, Hiramuki Y, Sogabe M, Kuriki M, Choi M, Wang Z, Kawahara A, Kawakami K, Sehara-Fujisawa A.
Organizer
48th Annual meeting of the Japanese Society of Developmental Biologists
Place of Presentation
茨城県つくば市
Year and Date
2015-06-05
Related Report
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