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Transgenerational effects associated with radiation exposure in bulls after Fukushima accident

Research Project

Project/Area Number 15K11952
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 復興農学
Research InstitutionNiigata University

Principal Investigator

Hideaki Yamashiro  新潟大学, 自然科学系, 助教 (60612710)

Co-Investigator(Kenkyū-buntansha) 杉村 智史  東京農工大学, (連合)農学研究科(研究院), 特任准教授 (00728454)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords福島原発事故 / 被災雄牛 / 経世代 / エクソン解析 / メタボローム解析 / 被災雄牛由来子牛 / 精子 / 仔牛 / 継世代 / 雄性ゲノムクローニング
Outline of Final Research Achievements

We aimed to investigate the effect of exporting radiation for 6 months and 2 years in the ex-evacuation zone, a 20-km radius region surrounding the FNPP, on whole genome exome mutation of offspring associated with radiated bulls. As a result, there were no hereditary phenotypic alterations in the whole genome exome regions of calves associated with paternal exposure to ionizing radiation. Furthermore, we analysed transgenerational effects on calf on the blood plasma metabolome in order to detect alterations associated with paternal exposure to radiation. There were no significant transgenerational effects on the blood plasma metabolome in calf obtained by AI using sperm from LDR-radiated bull in the FNPP ex-evacuation zone. In calves produced by using sperm of Fukushima bulls, the radiation effects were extremely low. Thus, the results of our study would contribute to the reconstruction of the Fukushima livestock industry and facilitate devising food safety and security measures.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] Analysis of the Effect of Chronic and Low-Dose Radiation Exposure on Spermatogenic Cells of Male Large Japanese Field Mice (Apodemus speciosus ) after the Fukushima Daiichi Nuclear Power Plant Accident.2016

    • Author(s)
      Takino S, Yamashiro H, Sugano Y, Fujishima Y, Nakata A, Kasai K, Hayashi G, Urushihara Y, Suzuki M, Shinoda H, Miura T, Fukumoto M.
    • Journal Title

      Radiat Res

      Volume: 187 Issue: 2 Pages: 161-168

    • DOI

      10.1667/rr14234.1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 被災雄牛における継世代影響評価2016

    • Author(s)
      山城秀昭, 高橋秀和, 藤 晋一, 漆原佑介, 桑原義和, 鈴木正敏, 阿部靖之, 杉村智史, 福田智一, 木野康志, 磯貝恵美子, 福本 学.
    • Journal Title

      無菌生物誌

      Volume: 46 Pages: 22-23

    • Related Report
      2016 Research-status Report
  • [Journal Article] Electron probe X-ray microanalysis of boar and inobuta testes after the Fukushima accident2015

    • Author(s)
      Yamashiro H, Abe Y, Hayashi G, Urushihara Y, Kuwahara Y, Suzuki M, Kobayashi J, Kino Y, Fukuda T, Tong B, Takino S, Sugano Y, Sugimura S, Yamada T, Isogai E, Fukumoto M.
    • Journal Title

      Journal of Radiation Research

      Volume: 56 Issue: suppl 1 Pages: 42-47

    • DOI

      10.1093/jrr/rrv070

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Transgenerationaleffects on calf spermatogenesis and metabolomeassociated with paternal exposure to radiation after the Fukushima Nuclear Power Plant accident2017

    • Author(s)
      Yamashiro H, Fukumoto M
    • Organizer
      2017 International Symposium on Morphological Sciences
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 電子線マイクロアナライザによる被災アカネズミ精巣の元素分析2016

    • Author(s)
      大平拓也, 伊藤 洵, 菅原淳史, 山城秀昭,中田章史, 鈴木正敏, 有吉健太郎, 葛西宏介, 篠田 壽, 三浦富智, 福本 学.
    • Organizer
      日本放射線影響学会第59回大会
    • Place of Presentation
      JMSアステールプラザ広島(広島県・広島市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 被災アカネズミにおける精巣のEPMA分析2016

    • Author(s)
      大平拓也, 伊藤 洵, 藤嶋洋平, 山城秀昭,中田章史, 鈴木正敏, 有吉健太郎, 葛西宏介, 篠田 壽, 三浦富智, 福本 学.
    • Organizer
      第3回 福島原発事故による周辺生物への影響に関する専門研究会
    • Place of Presentation
      京都大学原子炉実験所(大阪府・熊取町)
    • Year and Date
      2016-08-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 被災雄牛における継世代影響評価2016

    • Author(s)
      山城秀昭, 高橋秀和, 藤 晋一, 漆原佑介, 桑原義和, 鈴木正敏, 阿部靖之, 杉村智史, 福田智一, 木野康志, 磯貝恵美子, 福本 学
    • Organizer
      第49回無菌生物ノートバイオロジー学会
    • Place of Presentation
      仙台ガーデンパレス(宮城県・仙台市)
    • Year and Date
      2016-01-29
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 被災雄牛における継世代影響評価の試み2015

    • Author(s)
      山城秀昭
    • Organizer
      福島原発事故による周辺生物への影響に関する専門研究会
    • Place of Presentation
      京都大学原子炉実験所(大阪府・熊取市)
    • Year and Date
      2015-08-10
    • Related Report
      2015 Research-status Report
  • [Presentation] Effects of radiation exposure on transgenerational inheritance in bulls after the Fukushima Nuclear Power Plant accident2015

    • Author(s)
      Yamashiro H, Tong B, Takino S, Sugano Y, Tanaka S, Nishikawa T, Yoshida C, Abe Y, Hayashi G, Urushihara Y, Kuwahara Y, Suzuki M, Takahashi H, Fuji S, Isogai E, Fukumoto M
    • Organizer
      15th International Congress of Radiation Research (ICRR)
    • Place of Presentation
      Kyoto International conference Centre (Kyoto Prefecture, Kyoto City)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 被災家畜における生殖器官・機能影響の評価2015

    • Author(s)
      山城秀昭、瀧野祥、菅野有晃、漆原佑介、鈴木正敏、桑原義和、阿部靖之、小林 仁、福田智一、木野康志、篠田 壽、磯貝恵美子、福本 学
    • Total Pages
      135
    • Publisher
      京都大学原子炉実験所レポート (KURRI Report)
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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