Low-dose radiation risk assessment through investigating the mechanisms of low-dose radiation induced EMT

• Project/Area Number: 15K12207
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Hiroshima University
• Principal Investigator: Kamiya Kenji 広島大学, 原爆放射線医科学研究所, 教授 (60116564)
• Co-Investigator(Kenkyū-buntansha): IIZUKA DAISUKE 広島大学, 原爆放射線医科学研究所, 助教 (00455388) ; SASATANI MEGUMI 広島大学, 原爆放射線医科学研究所, 助教 (80423052)
• Project Period (FY): 2015-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 上皮間葉転換 / 低線量放射線 / 腫瘍増殖因子（TGF-beta） / 過酸化水素

Outline of Final Research Achievements

Estimating the risk of low-dose radiation is the important issue for humans. It has been reported that low-dose radiation exposure facilitated transforming growth factor (TGF-β) mediated Epithelial to Mesenchymal Transition (EMT). EMT, which are involved in many important biological process, is also known to be involved in tumorigenesis. To better understand the risks by low dose radiation exposure, we investigated whether reactive oxygen species (ROS) can facilitate TGF-β mediated EMT. We observed that hydrogen peroxide could facilitate TGF-β mediated EMT. These results suggested that ROS played an important role in the facilitation of TGF-β mediated EMT by low-dose radiation exposure.

Research Products

• [Journal Article] γ線照射環境での細胞運命決定とその制御因子の同定 (2016)
  • Author(s): 曹麗麗, 河合秀彦, 稲葉俊哉, 鈴木文男, 神谷研二
  • Journal Title: 広島医学 Volume: 印刷中
  • Peer Reviewed
• [Journal Article] 低線量放射線被ばくによる乳腺への影響とそのメカニズムについて (2016)
  • Author(s): 飯塚大輔, 笹谷めぐみ, 神谷研二
  • Journal Title: 広島医学 Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Hepcidin-2 in mouse urine as a candidate radiation-responsive molecule. (2016)
  • Author(s): Iizuka D, Yoshioka S, Kawai H, Okazaki E, Kiriyama K, Izumi S, Nishimura M, Shimada Y, Kamiya K, Suzuki F.
  • Journal Title: J Radiat Res Volume: 57(2) Issue: 2 Pages: 142-149
  • DOI: 10.1093/jrr/rrv098
  • Peer Reviewed / Open Access
• [Journal Article] 放射線の人体への影響について～3.11からの福島の現状をふまえて (2015)
  • Author(s): 神谷研二
  • Journal Title: 福山医学 Volume: 22 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Increase in dicentric chromosome formation after a single CT scan in adults. (2015)
  • Author(s): Abe Y, Miura T, Yoshida MA, Ujiie R, Kurosu Y, Kato N, Katafuchi A, Tsuyama N, Ohba T, Inamasu T, Shishido F, Noji H, Ogawa K, Yokouchi H, Kanazawa K, Ishida T, Muto S, Ohsugi J, Suzuki H, Ishikawa T, Kamiya K, Sakai A.
  • Journal Title: Scinetific Reports Volume: 9 Issue: 1 Pages: 13882-13882
  • DOI: 10.1038/srep13882
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-term effects of radiation exposure on health. (2015)
  • Author(s): Kamiya K, Ozasa K, Akiba S, Niwa O, Kodama K, Takamura N, Zaharieva EK, Kimura Y, Wakeford R
  • Journal Title: Lancet Volume: 386 Issue: 9992 Pages: 469-78
  • DOI: 10.1016/s0140-6736(15)61167-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification of low-dose responsive metabolites in X-irradiated human B lymphoblastoid cells and fibroblasts. (2015)
  • Author(s): Tsuyama N, Mizuno H, Katafuchi A, Abe Y, Kurosu Y, Yoshida M, Kamiya K, Sakai A
  • Journal Title: J Radiat Res. Volume: 56 Issue: 1 Pages: 46-58
  • DOI: 10.1093/jrr/rru078
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 過酸化水素によるTGF-betaを介したEMT促進現象とそのメカニズムについて. (2015)
  • Author(s): 飯塚大輔, 笹谷めぐみ, 神谷研二
  • Organizer: 第38回日本分子生物学会・第88回日本生化学会合同大会(BMB2015)
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] ハイスループット解析技術による放射線照射環境での細胞応答の研究. (2015)
  • Author(s): 河合秀彦, 曹麗麗, 金井昭教, 稲葉俊哉, 神谷研二, 鈴木文男
  • Organizer: 第1回放射線ワークショップ「未来に繋ぐ放射線研究」
  • Place of Presentation: 富山
  • Year and Date: 2015-10-17
• [Presentation] 低線量被ばくで増加する乳腺幹細胞頻度の系統差とそのメカニズム. (2015)
  • Author(s): 飯塚大輔, 笹谷めぐみ, 神谷研二
  • Organizer: 第1回放射線ワークショップ「未来に繋ぐ放射線研究」
  • Place of Presentation: 富山
  • Year and Date: 2015-10-16
• [Presentation] 放射線を受けた乳腺における幹細胞の動態は系統により異なる. (2015)
  • Author(s): 飯塚大輔, 笹谷めぐみ, 神谷研二
  • Organizer: 第158回日本獣医学会
  • Place of Presentation: 十和田
  • Year and Date: 2015-09-07
• [Presentation] 低線量放射線被ばくによる乳腺幹細胞頻度増加の系統差. (2015)
  • Author(s): 飯塚大輔, 笹谷めぐみ, 神谷研二
  • Organizer: 第24回乳癌基礎研究会
  • Place of Presentation: いわき
  • Year and Date: 2015-09-05
• [Presentation] 低線量放射線被ばくによる乳腺幹細胞頻度への影響解析. (2015)
  • Author(s): 飯塚大輔, 笹谷めぐみ, 神谷研二
  • Organizer: 第40回中国地区放射線影響研究会
  • Place of Presentation: 東広島
  • Year and Date: 2015-07-17
• [Presentation] 福島原発事故と低線量放射線の健康影響. (2015)
  • Author(s): 神谷研二
  • Organizer: 第42回日本毒性学会学術年会
  • Place of Presentation: 金沢
  • Year and Date: 2015-06-30
  • Invited
• [Presentation] 低線量放射線被ばくによる乳腺への影響とそのメカニズムについて. (2015)
  • Author(s): 飯塚大輔, 笹谷めぐみ, 神谷研二
  • Organizer: 第56回原子爆弾後障害研究会
  • Place of Presentation: 広島
  • Year and Date: 2015-06-07
• [Presentation] γ線照射環境での細胞運命決定とその制御因子の同定. (2015)
  • Author(s): 曹麗麗, 河合秀彦, 稲葉俊哉, 鈴木文男, 神谷研二
  • Organizer: 第56回原子爆弾後障害研究会
  • Place of Presentation: 広島
  • Year and Date: 2015-06-07
• [Presentation] The function of Chromatin Remodeling Complexes in Cell-fate Decision in Response to Chronic Ionizing Irradiation. (2015)
  • Author(s): Cao L, Kawai H, Inaba T, Suzuki F, Kamiya K
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto
  • Year and Date: 2015-05-28
  • Int'l Joint Research
• [Presentation] An Integrated Approach Using High-throughput Sequencing and Imaging Technologies to the Study of Cellular Responses to Low Dose Radiation. (2015)
  • Author(s): Kawai H, Cao L, Shimizu N, Matsui H, Kanai A, Hirouchi T, Inaba T, Kamiya K, Suzuki F.
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto
  • Year and Date: 2015-05-28
  • Int'l Joint Research
• [Presentation] The Strain-dependence of the Increase of Mammary Stem Cell Self-renewal by Radiation Exposure. (2015)
  • Author(s): Iizuka D, Sasatani M, Barcellos-Hoff M.H., Kamiya K.
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: kyoto
  • Year and Date: 2015-05-28
  • Int'l Joint Research
• [Presentation] ICRR Special Lecture; Health Effects of the Fukushima Nuclear Accident and Research on Low Dose Radiation. (2015)
  • Author(s): Kamiya, K.
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto
  • Year and Date: 2015-05-27
  • Int'l Joint Research / Invited