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Investigation of relationships between physica chemical and biological cheracteristics of Asian dust particles and pathogenesis of allergic conjunctivitis

Research Project

Project/Area Number 15K12219
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Environmental impact assessment
Research InstitutionFukuoka University

Principal Investigator

Nishita Chiharu  福岡大学, 福岡から診る大気環境研究所, ポスト・ドクター (00572463)

Co-Investigator(Kenkyū-buntansha) 内尾 英一  福岡大学, 医学部, 教授 (70232840)
Co-Investigator(Renkei-kenkyūsha) HIRABAYASHI Motohiro  国立極地研究所, 特任助手 (20399356)
HARA Keiichiro  福岡大学, 理学部, 助教 (10390593)
HAYASHI Masahiko  福岡大学, 理学部, 教授 (50228590)
Research Collaborator KO Ryota  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords黄砂 / 健康影響 / 酸化能 / 遷移金属 / 結膜炎 / アレルギー / 大気微粒子 / 健康影響評価
Outline of Final Research Achievements

Asian dust affects Japan especially in spring. Previous studies have observed association of Asian dust events with worsening of allergenic diseases. However, characteristics of Asian dust particles that cause the adverse health effects and its relation to pathogenesises of the allergenic diseases have been poorly understood. To elucidate the characteristics of dust particles that can be a factor causing the allergenic reactions and the pathogenesis of the allergenic diseases relating to Asian dust exposure, this study performed atmospheric aerosol sampling and collected questionnaires and tear samples from healthy subjects. Results of the atmospheric observation revealed that oxidative potential of coarse particles increases during Asian dust events. Soluble manganese is suggested to be an important factor causing the high oxidative potential of coarse particles during Asian dust event.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016 2015 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Aerosol Optical Characteristics in Fukuoka and Beijing Measured by Integrating Nephelometer and Aethalometer: Comparison of Source and Downstream Regions2018

    • Author(s)
      Uchiyama A., B. Chen, A. Yamazaki, G. Shi, R. Kudo, C. Nishita-Hara, M. Hayashi, A. Habib and T. Matsunaga
    • Journal Title

      Journal of the Meteorological Society of Japan. Ser. II

      Volume: 96 Issue: 2 Pages: 215-240

    • DOI

      10.2151/jmsj.2018-026

    • NAID

      130006694323

    • ISSN
      0026-1165, 2186-9057
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Monthly and Diurnal Variation of the Concentrations of Aerosol Surface Area in Fukuoka, Japan, Measured by Diffusion Charging Method2017

    • Author(s)
      Kiriya Miho、Okuda Tomoaki、Yamazaki Hana、Hatoya Kazuki、Kaneyasu Naoki、Uno Itsushi、Nishita Chiharu、Hara Keiichiro、Hayashi Masahiko、Funato Koji、Inoue Kozo、Yamamoto Shigekazu、Yoshino Ayako、Takami Akinori
    • Journal Title

      Atmosphere

      Volume: 8 Issue: 7 Pages: 114-114

    • DOI

      10.3390/atmos8070114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 黄砂とアレルギー:黄砂とアレルギー性結膜炎の関係解明に向けて2015

    • Author(s)
      西田千春
    • Journal Title

      アレルギーの臨床

      Volume: 35 Pages: 60-62

    • Related Report
      2015 Research-status Report
  • [Presentation] 春季の福岡市における大気エアロゾル粒子の酸化能2018

    • Author(s)
      西田千春、平林幹啓、原圭一郎、林 政彦
    • Organizer
      第35回エアロゾル科学・技術研究討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effects of Asian dust particles in a reconstructed cultured human corneal epithelial model2018

    • Author(s)
      Ryota Ko, Masahiko Hayashi, Miho Tanaka, Eiichi Uchio
    • Organizer
      ARVO2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 福岡市における大気エアロゾル濃度とその要因2016

    • Author(s)
      西田千春, 原圭一郎, 林政彦
    • Organizer
      第33回エアロゾル科学・技術研究討論会
    • Place of Presentation
      大阪府立大学
    • Year and Date
      2016-08-31
    • Related Report
      2016 Research-status Report
  • [Remarks] 福岡から診る大気環境研究所ホームページ

    • URL

      http://www.se.fukuoka-u.ac.jp/wordpress/fiteh/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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