Dietary factors and aging control: Glycosylation modified diets
Project/Area Number |
15K12340
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Eating habits
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Research Institution | The University of Tokushima |
Principal Investigator |
MIYAMOTO Kenichi 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (70174208)
|
Co-Investigator(Kenkyū-buntansha) |
瀬川 博子 徳島大学, 大学院医歯薬学研究部(医学系), 講師 (70325257)
辰巳 佐和子 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (80420545)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | リン / 寿命 / 腎臓 / 食事 / klotho / 糖鎖 / 亜鉛 / ミトコンドリア / Klotho |
Outline of Final Research Achievements |
Dietary modifications such as calorie restrictions have a lifespan extension effect. Klotho deficient (KL) mice are short-lived, aged-promoted model mice. The inorganic phosphate (Pi) -restricted diet prolongs the life span of KL mice and restores its phenotype. In this study, we investigated whether Pi-restricted diet causes the modification of the N-glycosylation of Npt2c. By Pi-restricted diet, Npt2c and Klotho were induced, and the N-glycosylation pattern of Npt 2c was changed. KLNpt2c (Klotho/Npt2c DKO) mice showed the rescued KL phenotypes. In conclusion, Pi restriction was considered to be a diet inducing N-glycan modification
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Report
(3 results)
Research Products
(70 results)
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[Journal Article] Present statsus of renal replacement therapy at 2015 in Asian countries (Myanmar, Vietnam, Thailand, China, and Japan).2017
Author(s)
Hydo T, Hirakawa N, Hayashi M, Mand Than KM, tuyen DG, Hu LW, Naramura T, Miyamoto K, Yamashita AC.
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Journal Title
Renal Replace Ther.
Volume: 3:11
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Peer Reviewed / Open Access
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[Journal Article] Niacin and Chronic Kidney Disease2015
Author(s)
Taketani Y, Masuda M, Yamanaka-Okumura H, Tatsumi S, Segawa H, Miyamoto K, Takeda E, Yamamoto H.
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Journal Title
Journal of Nutritional Science and Vitaminology
Volume: 61
Issue: Supplement
Pages: S173-S175
DOI
NAID
ISSN
0301-4800, 1881-7742
Related Report
Peer Reviewed / Open Access
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[Presentation] リン代謝動態の概日リズム形成機序解明.2016
Author(s)
高濱和子,辰巳佐和子,宮川淳美,藤井理,新垣友啓,緒方雅央,木下瑛美,金子一郎,瀬川博子,宮本賢一.
Organizer
第49回日本栄養・食糧学会 中国・四国支部大会
Place of Presentation
徳島大学(徳島県徳島市)
Year and Date
2016-11-12
Related Report
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[Presentation] 骨と健康寿命の検討について.2016
Author(s)
辰巳佐和子,藤井理,宮川淳美,宮本賢一.
Organizer
第63回日本栄養改善学会.
Place of Presentation
リンクステーションホール青森(青森県青森市)
Year and Date
2016-09-06
Related Report
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[Presentation] 形態の異なるリン化合物接種に対する生体への影響.2016
Author(s)
川端優佳,瀬川博子,結城志帆子,中山彰吾,藤井公,生田かよ,花崎愛,野津圭二郎, 西口詩織,金子一郎,辰巳佐和子,宮本賢一.
Organizer
第70回日本栄養・食糧学会大会.
Place of Presentation
神戸ポートピアホテル(兵庫県神戸市)
Year and Date
2016-05-13
Related Report
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[Presentation] 脳機能におけるビタミンDの役割について.2016
Author(s)
金子一郎,Hsieh Jui-Cheng,Whitfield G.Kerr,辰巳佐和子,瀬川博子,宮本賢一,Haussler Mark R,Jurutka Peter W.
Organizer
第19会日本病態栄養学会年次学術集会.
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-01-09
Related Report
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[Presentation] 生体内リン代謝調節機構における唾液腺の関与.2015
Author(s)
生田かよ,瀬川博子,結城志帆子,金子一郎,西口詩織,石川康子,上田乙也,堀場直,寺社下浩一,福島直,宮本賢一.
Organizer
第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会.
Place of Presentation
神戸ポートアイランド(兵庫県神戸市)
Year and Date
2015-12-01
Related Report
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[Presentation] Genetic Deletion of NaPi-2c Rescue Phenotype of klotho Knockout Mice wi thout Improving Severe Hyperphosphat emia.2015
Author(s)
Ai Hanazaki, Hiroko Segawa, Kayo Ikuta, Toru Fujii,Ichiro Kaneko,Shihoko Yuki, Shiori Nishiguchi, Keijiro Notsu,Yuji Shiozaki, Sawako Tatsumi,Ken-ichi Miyamoto.
Organizer
American Society of Nephrology Kidney week.
Place of Presentation
San Diego Convention center(San Diego,CA,USA)
Year and Date
2015-11-04
Related Report
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[Presentation] 腎臓とリンの話題.2015
Author(s)
宮本賢一.
Organizer
第8回みゅーずたかつき腎セミナー.
Place of Presentation
大阪医科大学(大阪府高槻市)
Year and Date
2015-09-26
Related Report
Invited
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[Presentation] リンと食事の話題.2015
Author(s)
宮本賢一.
Organizer
第1回腎と栄養懇話会.
Place of Presentation
ホテルグランド東雲(茨城県つくば市)
Year and Date
2015-09-02
Related Report
Invited
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[Presentation] 食餌性リンの話題.2015
Author(s)
宮本賢一.
Organizer
第3回腎性抗加齢医学を考える会.
Place of Presentation
東京ドームホテル(東京都文京区)
Year and Date
2015-07-26
Related Report
Invited
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[Presentation] リンの話題.2015
Author(s)
宮本賢一.
Organizer
第13回日本女性腎臓病医の会(JSWN)総会.
Place of Presentation
サイプレスガーデンホテル(愛知県名古屋市)
Year and Date
2015-06-06
Related Report
Invited
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[Presentation] Niacin and Chronic Kidney Disease.2015
Author(s)
Yutaka Taketani, Masashi Masuda, Hisami Yamanaka-Okumura, Sawako Tatsumi, Ken-ichi Miyamoto,Eiji Takeda, Hironori Yamamoto.
Organizer
ACN2015 12th Asian Congress of Nutrition.
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2015-05-14
Related Report
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[Presentation] Bone-kidney axis regulating phosphate homeostasis: Study of osteocyte-ablated mice.2015
Author(s)
Haruna Sakaguchi, Sawako Tatsumi, Mao Ogata, Osamu Fujii, Tomohiro Arakaki, Atsumi Miyagawa,Kenta Nagamoto, Wako Takahama, Yukiko Hirobata, Akihiro Yasui, Ichiro Kaneko, Hiroko Segawa,Ken-ichi Miyamoto.
Organizer
ACN2015 12th Asian Congress of Nutrition.
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2015-05-14
Related Report
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[Presentation] Disruption of intestinal alkaline phosphatase (Akp3) affects the phosphate homeostasis.2015
Author(s)
Shihoko Yuki, Hiroko Segawa, Shohei Sasaki, Kayo Ikuta, Ichiro Kaneko, Toru Fujii, Ai Hanazaki,Shiori Nishiguchi, Keijiro Notsu, Eriko Aki, Yuji Shiozaki, Sawako Tatsumi, Ken-ichi Miyamoto.
Organizer
ACN2015 12th Asian Congress of Nutrition.
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2015-05-14
Related Report
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