| Project/Area Number |
15K12341
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Kyushu University |
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Principal Investigator |
Yasuo Shinobu 九州大学, 農学研究院, 准教授 (30574719)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 概日時計 / アミノ酸 / 時計遺伝子 / 高脂肪食 / 運動 / 食事リズム / 体内時計 |
|---|
| Outline of Final Research Achievements |
Disruption of the circadian clock by irregular illumination causes many diseases, including obesity and cancer. Previously, we identified the functional amino acids that can modulate the circadian clock in mice. This study clarified that these amino acids can prevent the adverse effect of chronic jet lag on affective behaviors. However, they also had negative effects on the expression of clock genes in the liver. We also clarified the relationship between irregular illumination and high fat diet, as well as the effect of exercise on affective behaviors. These data suggest that the circadian disruption can be improved by multiple factors, including amino acids, diet, and exercise.
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