2016 Fiscal Year Final Research Report
Coordination of circadian clock by amino acids and exercise
Project/Area Number |
15K12341
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Eating habits
|
Research Institution | Kyushu University |
Principal Investigator |
Yasuo Shinobu 九州大学, 農学研究院, 准教授 (30574719)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Keywords | 概日時計 / アミノ酸 / 時計遺伝子 / 高脂肪食 / 運動 |
Outline of Final Research Achievements |
Disruption of the circadian clock by irregular illumination causes many diseases, including obesity and cancer. Previously, we identified the functional amino acids that can modulate the circadian clock in mice. This study clarified that these amino acids can prevent the adverse effect of chronic jet lag on affective behaviors. However, they also had negative effects on the expression of clock genes in the liver. We also clarified the relationship between irregular illumination and high fat diet, as well as the effect of exercise on affective behaviors. These data suggest that the circadian disruption can be improved by multiple factors, including amino acids, diet, and exercise.
|
Free Research Field |
動物生理学
|