Coordination of circadian clock by amino acids and exercise
Project/Area Number |
15K12341
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Eating habits
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Research Institution | Kyushu University |
Principal Investigator |
Yasuo Shinobu 九州大学, 農学研究院, 准教授 (30574719)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 概日時計 / アミノ酸 / 時計遺伝子 / 高脂肪食 / 運動 / 食事リズム / 体内時計 |
Outline of Final Research Achievements |
Disruption of the circadian clock by irregular illumination causes many diseases, including obesity and cancer. Previously, we identified the functional amino acids that can modulate the circadian clock in mice. This study clarified that these amino acids can prevent the adverse effect of chronic jet lag on affective behaviors. However, they also had negative effects on the expression of clock genes in the liver. We also clarified the relationship between irregular illumination and high fat diet, as well as the effect of exercise on affective behaviors. These data suggest that the circadian disruption can be improved by multiple factors, including amino acids, diet, and exercise.
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Report
(3 results)
Research Products
(41 results)
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[Presentation] The role of skeletal muscle glucocorticoid receptors in photoperiodic response of depression-like behaviors2016
Author(s)
Tashiro, A., Goda, R., Shibata, S., Takai, Y., Ohtsuka, T., Uchiwa, T., Furuse, M., Yasuo, S.
Organizer
17th AAAP ANIMAL SCIENCE CONGRESS
Place of Presentation
九州産業大学(福岡)
Year and Date
2016-08-22
Related Report
Int'l Joint Research
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[Presentation] Effect of postnatal photoperiod on body weight and metabolomics profiles in skeletal muscle and plasma in mice2016
Author(s)
Uchiwa, T., Takai, Y., Tashiro, A., Shibata, S., Furuse, M., Yasuo, S.
Organizer
17th AAAP ANIMAL SCIENCE CONGRESS
Place of Presentation
九州産業大学(福岡)
Year and Date
2016-08-22
Related Report
Int'l Joint Research
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[Presentation] Effect of photoperiod during perinatal period on neurogenesis and stress-related behaviors in mice2016
Author(s)
Takai, Y., Kawai, M., Ogo, T., Ichinose, T., Furuya, S., Udo, H., Furuse, M., Yasuo, S.
Organizer
17th AAAP ANIMAL SCIENCE CONGRESS
Place of Presentation
九州産業大学(福岡)
Year and Date
2016-08-22
Related Report
Int'l Joint Research
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[Presentation] Differential levels of activity and stress response between Djungarian hamster (P. sungorus) and Robosovskii hamster (P. roborovskii)2016
Author(s)
Ikeda, H., Yamaguchi, T., Kodaira, M., Bahry, M.A., Chowdhury, V.S., Yasuo, S., Furuse, M.
Organizer
17th AAAP ANIMAL SCIENCE CONGRESS
Place of Presentation
九州産業大学(福岡)
Year and Date
2016-08-22
Related Report
Int'l Joint Research
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[Presentation] Aging and additive oxidative stress influences female ovarian functions in mice2016
Author(s)
Kodaira, M., Ikeda, H., Yamaguchi, T., Yamauchi, N., Chowdhury, V.S., Yasuo, S., Furuse, M.
Organizer
17th AAAP ANIMAL SCIENCE CONGRESS
Place of Presentation
九州産業大学(福岡)
Year and Date
2016-08-22
Related Report
Int'l Joint Research
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[Presentation] Restrain stress during pregnancy alters plasma amino acid composition and affects the growth and behavior of offspring in mice2016
Author(s)
Nishigawa, T., Takakura, M., Nagamachi, S., Chowdhury, V.S., Yasuo, S., Furuse, M.
Organizer
17th AAAP ANIMAL SCIENCE CONGRESS
Place of Presentation
九州産業大学(福岡)
Year and Date
2016-08-22
Related Report
Int'l Joint Research
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[Presentation] Lower locomotor activity is partially explained by brain dopamine metabolism in mice2016
Author(s)
Yamaguchi, T., Ikeda, H., Minaminaka, K., Kodaira, M., Chowdhury, V.S., Yasuo, S., Furuse, M.
Organizer
17th AAAP ANIMAL SCIENCE CONGRESS
Place of Presentation
九州産業大学(福岡)
Year and Date
2016-08-22
Related Report
Int'l Joint Research
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[Presentation] Effects of dietary L-ornithine on mother milk free amino acid composition and pup sleeping behavior in mice2016
Author(s)
Takakura, M., Nagamachi, S., Nishigawa, T., Chowdhury, V.S., Yasuo, S., Furuse, M.
Organizer
17th AAAP ANIMAL SCIENCE CONGRESS
Place of Presentation
九州産業大学(福岡)
Year and Date
2016-08-22
Related Report
Int'l Joint Research
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[Presentation] Effects of dietary L-serine on free amino acid composition of milk and performance of offspring in mice2016
Author(s)
Nagamachi, S., Takakura, M., Nishigawa, T., Chowdhury, V.S., Yasuo, S., Furuse, M.
Organizer
17th AAAP ANIMAL SCIENCE CONGRESS
Place of Presentation
九州産業大学(福岡)
Year and Date
2016-08-22
Related Report
Int'l Joint Research
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[Presentation] Effect of perinatal photoperiod on neurogenesis and affective behaviors in mice.2016
Author(s)
Takai, Y., Kawai, M., Ogo, T., Ichinose, T., Furuya, S., Udo, H., Furuse, M., Yasuo, S.
Organizer
64th NIBB Conference "Evolution of Seasonal Timers"
Place of Presentation
岡崎コンファレンスセンター(岡崎)
Year and Date
2016-04-22
Related Report
Int'l Joint Research
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