| Project/Area Number |
15K12498
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | National Institute of Advanced Industrial Science and Technology (2016)
Hokkaido University (2015) |
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Principal Investigator |
Kajimoto Kazuaki 国立研究開発法人産業技術総合研究所, 健康工学研究部門, 主任研究員 (10416216)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ドラッグデリバリーシステム / リポソーム / 肥満 / 脂肪組織 / 血管 / 免疫寛容 / 血管内皮細胞 / アポトーシス / ドラッグデリバリー |
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| Outline of Final Research Achievements |
We started this study to clarify a relationship between immunological reactions in adipose tissue caused by apoptosis of the adipose vasculature and anti-obesity effects of the adipose vessel-targeted nano DDS (drug delivery system). We established a quantitative method for evaluation of changes in macrophages, regulatory T cells and iNKT cells in adipose tissue by flow cytometry. In addition, we succeeded to develop a new method of large-scale preparation of the nano DDS for in vivo functional evaluation of cells of the immune system in adipose tissue. The functional assessments are being proceeded to elucidate the molecular mechanisms.
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