| Project/Area Number |
15K12523
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIRAISHI Koichi 東京慈恵会医科大学, 医学部, 准教授 (40426284)
KONDO Takashi 富山大学, 大学院医学薬学部, 教授 (40143937)
AOKI Manabu 東京慈恵会医科大学, 医学部, 教授 (90246364)
SUGITA Yoichi 東京慈恵会医科大学, 医学部, 非常勤講師 (40130174)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 超音波照射 / 固形がん / 超音波強度 / 生体透過率 / 超音波変調 / がん併用療法 / X線照射 / 一酸化窒素 / ラジオセンシタイザー |
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| Outline of Final Research Achievements |
Transmittance of ultrasound intensity through living body is the most important factor for safe and effective therapies by the use of ultrasound. We found substantial fluctuation in the transmittance due to interference phenomena of ultrasound. We obtained good agreements of the fluctuation between theoretical calculation and experimental measurements both with a phantom model and human samples. Furthermore, this fluctuation was successfully reduced by the use of modulated ultrasound. These findings can greatly contribute to advances of safe and effective ultrasound therapies.
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