| Project/Area Number |
15K12550
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition |
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Principal Investigator |
Tsunoda Shin-ichi 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 バイオ創薬プロジェクト, プロジェクトリーダー (90357533)
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| Project Period (FY) |
2015-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 生体機能利用 / 生体分子 / 薬学 / 癌 / exosome / EphA2 |
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| Outline of Final Research Achievements |
In this study, characterization of tumor-derived exosomes were performed to collect basic knowledge useful for development of drug delivery technology. We found that lung cancer cells secreted angiogenic exosomes and in vitro tube-formation and proliferation of endothelial cells was stimulated via EphA2 on the exosomes. These data and also further investigation of metastasis-related exosomes would provide useful knowledge for active targeting and other drug delivery technologies.
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