The effect of regular exercise on obesity-associated liver cancer from the aspect of gut microbiota and lipid metabolites
| Project/Area Number |
15K12709
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
Ohtani Naoko 東京理科大学, 理工学部応用生物科学科, 教授 (50275195)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 運動 / がん予防 / がん微小環境 / 規則的運動 / 肥満誘導性肝癌 / 肥満 |
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| Outline of Final Research Achievements |
We have previously revealed that obesity promoted hepatocellular carcinoma (HCC) development in mice treated with a chemical carcinogen. In this study, we tried to investigate whether exercise could reduce HCC development. Interestingly, we found that HCC development was attenuated in mice with regular Treadmill running. Moreover, obesity increased the level of blood deoxycholic acid (DCA), which was known to cause DNA damage, and the mice with Treadmill running showed reduced level of blood DCA, and increased expression of a bile acid transporter, oatp1a1(Organic anion transporting polypeptide 1a1) in their livers. Taken together, we suggest that a regular exercise such as running could prevent liver cholestasis, and thus obesity-associated HCC development by reducing blood DCA level.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity.2017
Author(s)
Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo M, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.
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Journal Title
Cancer Discov
Volume: in press
Issue: 5
Pages: 522-538
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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