• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The effect of regular exercise on obesity-associated liver cancer from the aspect of gut microbiota and lipid metabolites

Research Project

Project/Area Number 15K12709
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionTokyo University of Science

Principal Investigator

Ohtani Naoko  東京理科大学, 理工学部応用生物科学科, 教授 (50275195)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords運動 / がん予防 / がん微小環境 / 規則的運動 / 肥満誘導性肝癌 / 肥満
Outline of Final Research Achievements

We have previously revealed that obesity promoted hepatocellular carcinoma (HCC) development in mice treated with a chemical carcinogen. In this study, we tried to investigate whether exercise could reduce HCC development. Interestingly, we found that HCC development was attenuated in mice with regular Treadmill running. Moreover, obesity increased the level of blood deoxycholic acid (DCA), which was known to cause DNA damage, and the mice with Treadmill running showed reduced level of blood DCA, and increased expression of a bile acid transporter, oatp1a1(Organic anion transporting polypeptide 1a1) in their livers. Taken together, we suggest that a regular exercise such as running could prevent liver cholestasis, and thus obesity-associated HCC development by reducing blood DCA level.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (17 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (14 results) (of which Int'l Joint Research: 5 results,  Invited: 14 results) Book (1 results)

  • [Journal Article] Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity.2017

    • Author(s)
      Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo M, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.
    • Journal Title

      Cancer Discov

      Volume: in press Issue: 5 Pages: 522-538

    • DOI

      10.1158/2159-8290.cd-16-0932

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dysregulation of the Bmi-1/p16Ink4a pathway provokes an aging-associated decline of submandibular gland function.2015

    • Author(s)
      Yamakoshi K, Katano S, Iida M, Kimura H, Okuma A, Ikemoto-Uezumi M, Ohtani N, Hara E, Maruyama M.
    • Journal Title

      Aging Cell

      Volume: - Issue: 4 Pages: 1-9

    • DOI

      10.1111/acel.12337

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 肥満誘導性の腸内細菌代謝物による肝星細胞の細胞老化・SASPと肝がんの促進2016

    • Author(s)
      羅 智文、蒲池史卓、渡辺喜洋、大谷直子
    • Organizer
      第39回日本分子生物学会年会 シンポジウム 臓器老化による臓器間ネットワークの破綻を探る
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 細胞老化・SASPとその生体における役割2016

    • Author(s)
      大谷直子
    • Organizer
      日本放射線影響学会 第59回大会 シンポジウム 低線量放射線生物影響の課題への分子生物学的アプローチ
    • Place of Presentation
      JMSアステールプラザ(広島県・広島市)
    • Year and Date
      2016-10-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Cooperative role of gut microbial components and metabolites in obesity-associated liver cancer development.2016

    • Author(s)
      Tze Mun Loo and Naoko Ohtani
    • Organizer
      The 75th Annual Meeting of the Japanese Cancer Association Symposium 10(日本癌学会), Therapeutic vulnerability in infection/inflammation-associated cancer
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] p16INK4aによる個体老化の新たなメカニズム2016

    • Author(s)
      大谷直子
    • Organizer
      第89回日本生化学会大会 シンポジウム 加齢にともなう幹細胞変化と疾患の分子基盤
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-09-27
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The role of gut microbiota for obesity-associated liver cancer progression.2016

    • Author(s)
      Naoko Ohtani
    • Organizer
      Tokyo University of Science, International Symposium of the Center for Animal Disease Models 2016 -Metabolic disease and Aging-.
    • Place of Presentation
      Tokyo Garden Palace(Tokyo Japan)
    • Year and Date
      2016-07-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The role of gut microbiota for obesity-induced liver cancer development.2016

    • Author(s)
      Naoko Ohtani
    • Organizer
      RIKEN IMS-JSI International Symposium on Immunology 2016, Immune homeostasis and diseases.
    • Place of Presentation
      Pasifico Yokohama(Yokohama, Kanagawa Japan)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 肥満により増加する腸内細菌による肝がん進展メカニズム2016

    • Author(s)
      大谷直子
    • Organizer
      第16回抗加齢医学会総会シンポジウム 腸内フローラの臨床への展開
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-06-12
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The mechanism of obesity-induced liver cancer development through gut microbial components and metabolites.2016

    • Author(s)
      Naoko Ohtani
    • Organizer
      Bridging Biomedical Worlds meeting, Frontiers in Human Microbiota Symbiotic Interactions
    • Place of Presentation
      University of Hong Kong (Hong Kong, China)
    • Year and Date
      2016-05-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The Mechanism of Obesity-associated Liver Carcinogenesis: a co-operation between gut microbial metabolites and lipid.2016

    • Author(s)
      Naoko Ohtani
    • Organizer
      EASL, European association for the study of the liver, The International Liver Congress 2016
    • Place of Presentation
      Fira Barcelona Gran Via (Barcelona, Spain)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Obesity-induced gut microbial metabolite promotes liver cancer through senencnce-associated secretome2015

    • Author(s)
      Naoko Ohtani
    • Organizer
      24th Symposium on Intestinal Flora, Dynamism of Intestinal microbiota - pathophysiology of microbial metabolites
    • Place of Presentation
      ヤクルトホール(東京都)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 腸内細菌代謝産物による細胞老化の誘導と肝がん2015

    • Author(s)
      大谷直子
    • Organizer
      第11回 日本食品免疫学会学術大会、シンポジウム3 「老化と腸内環境、腸管機能」
    • Place of Presentation
      伊藤謝恩ホール(東京都)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Gut microbiota and obesity-associated hepatocarcinogenesis, The 74th Annual meeting of The JCA2015

    • Author(s)
      Naoko Ohtani
    • Organizer
      日本癌学会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 肥満により増加する腸内細菌による肝がん促進機構2015

    • Author(s)
      大谷直子、羅 智文
    • Organizer
      第36回 日本肥満学会 シンポジウム「肥満と臓器障害」
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 肥満による肝がん促進機構 ~腸内細菌代謝物の関与~2015

    • Author(s)
      大谷直子
    • Organizer
      第18回 日本臨床腸内微生物学会総会・学術集会 教育講演 III 病態と治療法を探る
    • Place of Presentation
      日本医科大学附属病院橘桜会館(東京都)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] Chronic Inflammation (Msayuki Miyasaka and Kiyoshi Takatsu Editors) Part III No 15. Cellular Senescence as a Novel Mechanism of Chronic Inflammation and Cancer Progression2016

    • Author(s)
      Naoko Ohtani
    • Total Pages
      702
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi