| Project/Area Number |
15K12714
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | Mie University (2016-2017)
Kinki University (2015) |
|---|
Principal Investigator |
Itoh Tomohiro 三重大学, 生物資源学研究科, 准教授 (30435854)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
AKAO Yukihiro 岐阜大学, 大学院連合創薬医療情報研究科, 教授 (00222505)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | エクソソーム / マイクロRNA / 骨細胞 / 骨芽細胞 / 分化 / メカニカルストレス / 破骨細胞 / 膜微小胞 / 骨代謝 / microRNA / exosome / miRNA |
|---|
| Outline of Final Research Achievements |
In this study, we demonstrated the effect of exosome (MS-Ov) released from mechanical stress-stimulated osteocyte on osteogenesis or osteoclastogenesis. The MS-Ov treatment induced osteoclast formation, but had no change in osteoblast differentiation. Moreover, MS-Ov contained miRNAs targeting osteoclastogenesis-related molecules. From these results, it was found that MS-Ov gives more priority to osteoclastogenesis than to osteogenesis.
|
