| Project/Area Number |
15K12721
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Childhood science (childhood environment science)
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| Research Institution | Osaka University |
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Principal Investigator |
TANIIKE MASAKO 大阪大学, 連合小児発達学研究科, 教授 (30263289)
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| Co-Investigator(Kenkyū-buntansha) |
毛利 育子 大阪大学, 連合小児発達学研究科, 准教授 (70399351)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 睡眠 / 脳発達 / プロスタグランジンD2 / 小児 / PGD2 / 睡眠不足 / 遅寝 / 発達 / 夜間睡眠 / tetranol-PGDM / スクリーニング / 尿 / 実行機能 / tetranor-PGDM |
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| Outline of Final Research Achievements |
Sleep is a physiological state caused by multiple mechanisms, one of which is a prostaglandin D2 (PGD2), an endogenous sleep-promoting substance. We investigated whether the content of tetranor-PGDM, a metabolite of PGD2, is a marker of the quantity of child sleep using the morning urines from 686 kindergarten children.
The t-PGDM urinary content showed no sex difference. Two groups were recognized; the one showed the urinary t-PGDM content having a reverse correlation with sleep time and the other without such correlation. Its content and bedtime showed a negative correlation.
These lines of evidence suggested that the urinary t-PGDM content may be a biomarker for sleep quantity.
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| Academic Significance and Societal Importance of the Research Achievements |
睡眠は脳発達に重要な生理状態であるが、日本の小児は先進各国に比し睡眠時間が短いことが知られている。プロスタグランジンD2は強力な睡眠誘発物質であり、断眠など睡眠不足時に髄膜で産生され、代謝されて尿中にtetranor-PGDMとして排泄される。我々は、このtetranor-PGDMが睡眠不足の指標にならないかを検討した。睡眠不足が定量できれば、睡眠衛生指導が容易になる。
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