Development of biochemical markers for quality and/or quantity of child sleep
Project/Area Number |
15K12721
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Childhood science (childhood environment science)
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Research Institution | Osaka University |
Principal Investigator |
TANIIKE MASAKO 大阪大学, 連合小児発達学研究科, 教授 (30263289)
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Co-Investigator(Kenkyū-buntansha) |
毛利 育子 大阪大学, 連合小児発達学研究科, 准教授 (70399351)
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Project Period (FY) |
2015-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
Keywords | 睡眠 / 脳発達 / プロスタグランジンD2 / 小児 / PGD2 / 睡眠不足 / 遅寝 / 発達 / 夜間睡眠 / tetranol-PGDM / スクリーニング / 尿 / 実行機能 / tetranor-PGDM |
Outline of Final Research Achievements |
Sleep is a physiological state caused by multiple mechanisms, one of which is a prostaglandin D2 (PGD2), an endogenous sleep-promoting substance. We investigated whether the content of tetranor-PGDM, a metabolite of PGD2, is a marker of the quantity of child sleep using the morning urines from 686 kindergarten children. The t-PGDM urinary content showed no sex difference. Two groups were recognized; the one showed the urinary t-PGDM content having a reverse correlation with sleep time and the other without such correlation. Its content and bedtime showed a negative correlation. These lines of evidence suggested that the urinary t-PGDM content may be a biomarker for sleep quantity.
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Academic Significance and Societal Importance of the Research Achievements |
睡眠は脳発達に重要な生理状態であるが、日本の小児は先進各国に比し睡眠時間が短いことが知られている。プロスタグランジンD2は強力な睡眠誘発物質であり、断眠など睡眠不足時に髄膜で産生され、代謝されて尿中にtetranor-PGDMとして排泄される。我々は、このtetranor-PGDMが睡眠不足の指標にならないかを検討した。睡眠不足が定量できれば、睡眠衛生指導が容易になる。
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Report
(5 results)
Research Products
(27 results)
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[Journal Article] Clasmatodendrosis is associated with dendritic spines and does not represent autophagic astrocyte death in influenza-associated encephalopathy.2019
Author(s)
Tachibana M, Mohri I, Hirata I, Kuwada A, Kimura-Ohba S, Kagitani-Shimono K, Fushimi H, Inoue T, Shiomi M, Kakuta Y, Takeuchi M, Murayama S, Nakayama M, Ozono K, Taniike M
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Journal Title
Brain and Development.
Volume: 41
Issue: 1
Pages: 85-95
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Japanese Sleep Questionnaire for Elementary Schoolers (JSQ-ES): validation and population-based score distribution.2018
Author(s)
Kuwada A, Mohri I, Asano R, Matsuzawa S, Kato-Nishimura K, Hirata I, Mitsuhosi T, Kagitani-Shimono K, Nakanishi M, Tachibana M, Ohno Y, Taniike M.
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Journal Title
Sleep Medicine
Volume: 41
Pages: 69-77
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Delayed mismatch field latencies in autism spectrum disorder with abnormal auditory sensitivity: a magnetoencephalographic study.2017
Author(s)
Matsuzaki J, Kagitani-Shimono K, Sugata H, Hanaie R, Nagatani F, Yamamoto T, Tachibana M, Tominaga K, Hirata M, Mohri I, and Taniike M.
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Journal Title
Front Hum Neurosci.
Volume: 11
Pages: 446-446
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP).2015
Author(s)
hibasaki Y, Hayata-Takano A, Hazama K, Nakazawa T, Shintani N, Kasai A, Nagayasu K, Hashimoto R, Tanida M, Katayama T, Matsuzaki S, Yamada K, Taniike M, Onaka Y, Ago Y, Waschek JA, Köves K, Reglődi D, Tamas A, Matsuda T, Baba A, Hashimoto H.
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Journal Title
Neuroscience
Volume: 297
Pages: 95-104
DOI
Related Report
Peer Reviewed
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[Presentation] Development of an interactive smartphone application toward improvement of sleep habits in Japanese infant.2017
Author(s)
Yoshizaki A, Aoi Y, Yamamoto T, Murata E, Okada S, Matsuzawa S, Hoshino K, Kato-Nishimura K, Miyata R, Tachibana M, Mohri I, Taniike M.
Organizer
World sleep Society 2017
Related Report
Int'l Joint Research
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