Chemical probes for long time imaging of osteoclasts function by optimization of emission wavelength and photostability
Project/Area Number |
15K12754
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Chemical biology
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Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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Keywords | in vivoイメージング / 蛍光プローブ / 破骨細胞 / 光安定性 |
Outline of Final Research Achievements |
Chemical probes were developed for in vivo imaging of activated osteoclasts by using two-photon excitation microscopy. As fluorescent probes, rhodamine derivatives with pH-activatable property and red-shifted emission were designed and synthesized. The two-photon excitation microscopy images showed that fluorescence signals were observed at the specific regions in bone tissue in living mice.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Fabrication of ‘Clickable’ Polyfluorene Nanowires with High Aspect Ratio as Biological Sensing Platforms2016
Author(s)
T. Wasin, K. Enomoto, T. Sakurai, V. Padalkar, H. Cheng, M. Tang, A. Horio, D., Sakamaki, M. Omichi, A. Saeki, K. Kikuchi, Y. Hori, A. Chiba, Y. Saito, T. Kamiya, M. Sugimoto, S. Seki
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Journal Title
ACS Sensors
Volume: 6
Issue: 6
Pages: 766-774
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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