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A study on the neural basis of sustained reversal movement

Research Project

Project/Area Number 15K12769
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Basic / Social brain science
Research InstitutionNagoya University

Principal Investigator

Takagi Shin  名古屋大学, 理学研究科, 准教授 (90171420)

Research Collaborator Sugioka Takumi  
Kato Koharu  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords運動制御 / C. elegans / 光遺伝学 / 生体アミン / 後退運動 / 線虫 / 移動運動 / 神経回路
Outline of Final Research Achievements

Certain artificial stimuli can induce sustained backward locomotion (SBL) in animals. Taking advantage of the fact that optogenetic activation of a subset of neurons expressing the glr-1 gene induces sustained locomotion, we tried to elucidate the underlying cellular mechanisms. Activation of RIM neurons in addition to the command interneurons AVA and AVD is necessary for SBL. For longer SBL, activation of SMD and/or RMD appears to be critical. Although exogenous tyramine at a high concentration was reported to induce SBL, we found that tdc-1 mutants defective for the tyramine-synthesis performed longer SBL when glr-1 positive neurons were activated.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Optical silencing of body wall muscles induces pumping inhibition in Caenorhabditis elegans2017

    • Author(s)
      Takahashi Megumi、Takagi Shin
    • Journal Title

      PLOS Genetics

      Volume: 13 Issue: 12 Pages: 1007134-1007134

    • DOI

      10.1371/journal.pgen.1007134

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Astrocytic IP3Rs: Contribution to Ca2+ signalling and hippocampal LTP.2017

    • Author(s)
      Sherwood MW, Arizono M, Hisatsune C, Bannai H, Ebisui E, Sherwood JL, Panatier A, Oliet SH, Mikoshiba K.
    • Journal Title

      Glia

      Volume: 65 Issue: 1 Pages: 502-513

    • DOI

      10.1016/j.bbrc.2016.09.034

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterizing Semaphorin Signaling in vivo using C. elegans2017

    • Author(s)
      Nukazuka A, Takagi S
    • Journal Title

      Methods in Molecular Biology

      Volume: 1493 Pages: 485-498

    • DOI

      10.1007/978-1-4939-6448-2_34

    • ISBN
      9781493964468, 9781493964482
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] X-ray crystallographic structure of thermophilic rhodopsin: implications for high thermal stability and optogenetic function2016

    • Author(s)
      Tsukamoto T, Mizutani K, Hasegawa T, Takahashi M, Honda N, Hashimoto N, Shimono K, Yamashita K, Yamamoto M, Miyauchi S, Takagi S, Hayashi S, Murata T, Sudo Y.
    • Journal Title

      J. Biol. Chem.

      Volume: in press Issue: 23 Pages: 12223-12232

    • DOI

      10.1074/jbc.m116.719815

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] アニオンチャネルロドプシン2(ACR2)の線虫における超高感度光神経抑制活性2017

    • Author(s)
      山梨 太郎, 真木 美紗代, 小島 慧一, 高木 新 、須藤 雄気
    • Organizer
      第55回・生物物理学会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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