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Cortical architecture and function revealed by multimodal imaging and their association with behaviors

Research Project

Project/Area Number 15K12779
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Brain biometrics
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Hayashi Takuya  国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー (50372115)

Co-Investigator(Kenkyū-buntansha) 渡部 浩司  東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (40280820)
合瀬 恭幸  国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, リサーチアソシエイト (70519404)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsMRI / 拡散強調画像 / 機能的MRI画像 / 皮質マッピング / 機能的MRI画像法 / マルチモーダル / 神経突起 / 拡散MRI / PET / 機能的MRI / 安静時脳活動 / 神経伝達物質 / 皮質内分画化 / マルチモーダルイメージング
Outline of Final Research Achievements

The purpose of this study is to establish multi-modal information technologies using non-invasive brain imaging. We developed the technique for visualizing distributions of cortical neurite, connectivity, functional properties and collected brain imaging data from human and non-human primates. We achieved scientific publication on cortical neurite properties, which are associated with cortical myelin and microscopic architecture. We continue to establish the functional connectivity imaging and others to address the question how cortical multi-modal information can be useful to explain the behaviours.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (20 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (6 results) Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (10 results) (of which Int'l Joint Research: 6 results,  Invited: 6 results)

  • [Int'l Joint Research] セントルイス・ワシントン大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] オックスフォード大学(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ロンドン大学(英国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] ワシントン大学セントルイス(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Washington University(米国)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] University College London(英国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Neurite imaging reveals microstructural variations in human cerebral cortical gray matter2018

    • Author(s)
      Fukutomi, H., Glasser, M.F., Zhang, H., Autio, J.A., Coalson, T.S., Okada, T., Togashi, K., Van Essen, D.C., and Hayashi, T.
    • Journal Title

      Neuroimage

      Volume: in press Pages: 488-499

    • DOI

      10.1016/j.neuroimage.2018.02.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model2017

    • Author(s)
      Kikuchi Tetsuhiro、Morizane Asuka、Doi Daisuke、Magotani Hiroaki、Onoe Hirotaka、Hayashi Takuya、Mizuma Hiroshi、Takara Sayuki、Takahashi Ryosuke、Inoue Haruhisa、Morita Satoshi、Yamamoto Michio、Okita Keisuke、Nakagawa Masato、Parmar Malin、Takahashi Jun
    • Journal Title

      Nature

      Volume: 548 Issue: 7669 Pages: 592-596

    • DOI

      10.1038/nature23664

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MHC matching improves engraftment of iPSC-derived neurons in non-human primates.2017

    • Author(s)
      Morizane A, Kikuchi T, Hayashi T, Mizuma H, Takara S, Doi H, Mawatari A, Glasser MF, Shiina T, Ishigaki H, Itoh Y, Okita K, Yamasaki E, Doi D, Onoe H, Ogasawara K, Yamanaka S, Takahashi J.
    • Journal Title

      Nat Commun

      Volume: 8 Issue: 1 Pages: 385-385

    • DOI

      10.1038/s41467-017-00926-5

    • NAID

      120006365783

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular, Functional, and Structural Imaging of Major Depressive Disorder.2016

    • Author(s)
      Zhang, K., Zhu, Y., Zhu, Y., Wu, S., Liu, H., Zhang, W., Xu, C., Zhang, H., Hayashi, T., and Tian, M.
    • Journal Title

      Neurosci. bull.

      Volume: 32 Issue: 3 Pages: 273-285

    • DOI

      10.1007/s12264-016-0030-0

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 霊長類脳コネクトーム2018

    • Author(s)
      林 拓也
    • Organizer
      第20回ヒト脳機能マッピング学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Brain Connectome in Primates.2018

    • Author(s)
      Takuya Hayashi
    • Organizer
      International Symposium of Marmoset Science
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Challenges of Brain Connectome in Primates2017

    • Author(s)
      Takuya Hayashi
    • Organizer
      ABiS international symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト・霊長類動物脳コネクトームとパイプライン2017

    • Author(s)
      林 拓也
    • Organizer
      第1回ヒト脳イメージング研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] In vivo cortical dopamine D2 receptor binding in humans, macaques and marmosets2016

    • Author(s)
      Yokoyama Chihiro, Autio Joonas, Ose Takayuki, Kawasaki Akihiro, Takeda Chiho, Takahashi Kayo, Igesaka Ami, Doi Hisashi, Watanabe Yasuyoshi, Hayashi Takuya
    • Organizer
      Neuroscience 2016(Society for Neuroscience, SfN)
    • Place of Presentation
      San Diego Convention Center, San Diego, United States
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] MRI・PET を用いた大脳皮質可塑性の視覚化2016

    • Author(s)
      林 拓也
    • Organizer
      第46回日本臨床神経生理学会
    • Place of Presentation
      ホテルハマツ, 郡山
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] In vivo dopamine D2 receptor binding in the brain cortical surface of humans, macaque monkeys and common marmosets2016

    • Author(s)
      Yokoyama Chihiro, Autio Joonas, Kawasaki Akihiro, Takeda Chiho, Takahashi Kayo, Igesaka Ami, Doi Hisashi, Hayashi Takuya
    • Organizer
      第6回 日本マーモセット研究会大会
    • Place of Presentation
      東京大学農学部弥生講堂
    • Related Report
      2016 Research-status Report
  • [Presentation] Preclinical perspectives on the mechanism of aberrant brain network and dopamine dysfunction2016

    • Author(s)
      Hayashi Takuya, Autio Joonas
    • Organizer
      国立研究開発法人国立精神・神経医療研究センター脳病態統合イメージングセンター5周年記念国際シンポジウム
    • Place of Presentation
      国立精神・神経医療研究センター, 東京
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Image fusion using a novel multi-modal imaging marker2016

    • Author(s)
      Ose Takayuki, Watabe Hiroshi, Autio Joonas, Tanki Nobuyoshi, Igesaka Ami, Doi Hisashi, Wada Yasuhiro, Hayashi Takuya
    • Organizer
      NRM2016
    • Place of Presentation
      Boston, Mass., United States
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] High-resolution diffusion and structural MRI brain atlas of rhesus macaques2015

    • Author(s)
      Hayashi et al
    • Organizer
      Organization of Human Brain Mapping
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2015-06-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2022-02-03  

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