Cortical architecture and function revealed by multimodal imaging and their association with behaviors
| Project/Area Number |
15K12779
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Brain biometrics
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Hayashi Takuya 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー (50372115)
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| Co-Investigator(Kenkyū-buntansha) |
渡部 浩司 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (40280820)
合瀬 恭幸 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, リサーチアソシエイト (70519404)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | MRI / 拡散強調画像 / 機能的MRI画像 / 皮質マッピング / 機能的MRI画像法 / マルチモーダル / 神経突起 / 拡散MRI / PET / 機能的MRI / 安静時脳活動 / 神経伝達物質 / 皮質内分画化 / マルチモーダルイメージング |
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| Outline of Final Research Achievements |
The purpose of this study is to establish multi-modal information technologies using non-invasive brain imaging. We developed the technique for visualizing distributions of cortical neurite, connectivity, functional properties and collected brain imaging data from human and non-human primates. We achieved scientific publication on cortical neurite properties, which are associated with cortical myelin and microscopic architecture. We continue to establish the functional connectivity imaging and others to address the question how cortical multi-modal information can be useful to explain the behaviours.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Neurite imaging reveals microstructural variations in human cerebral cortical gray matter2018
Author(s)
Fukutomi, H., Glasser, M.F., Zhang, H., Autio, J.A., Coalson, T.S., Okada, T., Togashi, K., Van Essen, D.C., and Hayashi, T.
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Journal Title
Neuroimage
Volume: in press
Pages: 488-499
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] MHC matching improves engraftment of iPSC-derived neurons in non-human primates.2017
Author(s)
Morizane A, Kikuchi T, Hayashi T, Mizuma H, Takara S, Doi H, Mawatari A, Glasser MF, Shiina T, Ishigaki H, Itoh Y, Okita K, Yamasaki E, Doi D, Onoe H, Ogasawara K, Yamanaka S, Takahashi J.
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Journal Title
Nat Commun
Volume: 8
Issue: 1
Pages: 385-385
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Molecular, Functional, and Structural Imaging of Major Depressive Disorder.2016
Author(s)
Zhang, K., Zhu, Y., Zhu, Y., Wu, S., Liu, H., Zhang, W., Xu, C., Zhang, H., Hayashi, T., and Tian, M.
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Journal Title
Neurosci. bull.
Volume: 32
Issue: 3
Pages: 273-285
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] In vivo cortical dopamine D2 receptor binding in humans, macaques and marmosets2016
Author(s)
Yokoyama Chihiro, Autio Joonas, Ose Takayuki, Kawasaki Akihiro, Takeda Chiho, Takahashi Kayo, Igesaka Ami, Doi Hisashi, Watanabe Yasuyoshi, Hayashi Takuya
Organizer
Neuroscience 2016(Society for Neuroscience, SfN)
Place of Presentation
San Diego Convention Center, San Diego, United States
Related Report
Int'l Joint Research
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