The first attempt at active control of cellular function based on organelle-level thermal handling using nanoparticles
| Project/Area Number |
15K13321
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nano/Microsystems
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ナノ材料 / ナノバイオ / ドラッグデリバリーシステム / 透過膜ペプチド / EPR効果 / がん治療 / 膜透過ペプチド |
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| Outline of Final Research Achievements |
A new DDS carrier has been developed for cancer treatment. The nanoparticles are core-shell structure which is Fe3O4 for the core material and SiO2 for the porous shell material. The Fe3O4 is heated by applying alternating magnetic field, and brings out hyperthermia effect. The function of porous SiO2 is for support of anti-cancer drug. Additionally, the surface of the nanoparticles developed were covered with tLyP-1 peptides which home only cancer cells not normal cells, thereby we have succeeded an active targeting DDS for cancer treatment.
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Report
(3 results)
Research Products
(16 results)
