| Project/Area Number |
15K13588
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Petrology/Mineralogy/Economic geology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KAKEGAWA TAKESHI 東北大学, 大学院理学研究科, 教授 (60250669)
NAGASE TOSHIRO 東北大学, 総合学術博物館, 准教授 (10237521)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 鉱物 / RNA / テンプレート / 重合 / リン酸化 / ヌクレオチド / 鉱物テンプレート |
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| Outline of Final Research Achievements |
This study challenged the formation of oligonucleotides on mineral templates. Gypsum and calcite were used as the template mineral since they are ion crystal that potentially presented on the early Earth. Four kinds of adenosine nucleotides were investigated as the monomer of the oligomerization experiments. As the results, oligonucleotides were formed on gypsum template and glass template. However, the reproducibility of the results and the effects of template remain unclear. Thus, additional experiments are conducted.
Further, a borophosohate mineral, luneburgite, was investigated as the source of phosphorus in phosphorylation of nucleoside and found that this mineral serves phosphate effectively and promote the formation of nucleotide in a potential prebiotic environment. This work was published in Angwandte Chemie International Edition as a very important paper.
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