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Developments of plasmic nanoparticle assemblies that are applicable for immunoassay

Research Project

Project/Area Number 15K13729
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Analytical chemistry
Research InstitutionKagoshima University

Principal Investigator

Niidome Yasuro  鹿児島大学, 理工学域理学系, 教授 (50264081)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords金ナノロッド / コアシェルナノロッド / 2量体 / プラズモン / ナノ粒子組織体 / 表面プラズモンバンド
Outline of Final Research Achievements

Dimers of gold nanorods were prepared. After careful optimizations, we have found the efficient and reproducible experimental condition to give the nanorod dimers. TEM observation showed that the yield of the nanorod dimers was about 50 %. The nanorod dimers were fractionized by density gradient centrifugation. A stepwise density gradient using sucrose was successful to fractionize the nanorod dimers. The resultant solution contained about 70% of nanorod dimers.
To make various surface modification on gold-silver core-shell nanorods, we have developed a surface modification to disperse the nanorod in polar organic solvents that ware acetonitrile, dimethylsulfoxide, and dimethylformamide. The surface modification contributed the colloidal dispersion of the core-shell nanorods on which functional peptides adsorbed.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (26 results)

All 2017 2016 2015 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Acknowledgement Compliant: 4 results,  Open Access: 4 results) Presentation (16 results) (of which Int'l Joint Research: 6 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Ultra-High Sensitivity Detection of Gold Nanorods on a Blotting Membrane by Laser Induced Desorption/Ionization of Gold Ions2017

    • Author(s)
      Daiki Muko, Yuki Inoue, Atsushi Nishitani, Yasuro Niidome
    • Journal Title

      Analytical Methods

      Volume: 9 Issue: 7 Pages: 1177-1184

    • DOI

      10.1039/c6ay03315f

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Colloidal Dispersion of Gold Nanorods and Gold-Silver Core-Shell Nanorods in Polar Organic Solvents2017

    • Author(s)
      Takeharu Kitamura, Yasuro Niidome
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: 60 Issue: 2 Pages: 161-168

    • DOI

      10.1246/bcsj.20160297

    • NAID

      130005332367

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Gold-Silver Core-Shell Nanorods: Colorimetry of Horseradish Peroxidase (HRP) and Catalase2016

    • Author(s)
      Ayaka Kiya, Yukiko Tsuru, Yasuro Niidome
    • Journal Title

      Chemistry Letters

      Volume: 45 Issue: 12 Pages: 1376-1378

    • DOI

      10.1246/cl.160755

    • NAID

      130005475722

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stepwise Preparation of Spherical Gold Nanoparticles Passivated with Cationic Amphiphiles2016

    • Author(s)
      Yuki Inoue, Yo Tsutamoto, Daiki Muko, Kazuaki Nanamura, Tsuyoshi Sawada, Yasuro Niidome
    • Journal Title

      Analytical Sciences

      Volume: 32 Issue: 8 Pages: 875-880

    • DOI

      10.2116/analsci.32.875

    • NAID

      130005256425

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Anisotropic Gold-Based Nanoparticles: Their Preparation, Properties, and Applications2016

    • Author(s)
      Yasuro Niidome, Aung Thu Haine, TakuroNiidome
    • Journal Title

      Chemistry Letters

      Volume: 45 Issue: 5 Pages: 488-498

    • DOI

      10.1246/cl.160124

    • NAID

      130005150482

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assemblies of Gold Nanorods for Efficient SALDI Mass Spectrometry2016

    • Author(s)
      Masanori Fujii, Naotoshi Nakashima, Yasuro Niidome
    • Journal Title

      Optical Materials Express

      Volume: 6 Issue: 4 Pages: 1376-1383

    • DOI

      10.1364/ome.6.001376

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 銀シェル金ナノロッドの分光特性と基板固定2015

    • Author(s)
      新留康郎
    • Journal Title

      分光研究

      Volume: 64 Pages: 514-521

    • NAID

      40020674968

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Imaging Mass Spectrometry of Gold Nanorods Distributed in Tumor Tissue2015

    • Author(s)
      Takuro Niidome, Masanori Fujii, Naotoshi Nakashima, Yoshiki Katayama, Yasuro Niidome
    • Journal Title

      Chemistry Letters

      Volume: 44 Issue: 7 Pages: 931-933

    • DOI

      10.1246/cl.150258

    • NAID

      130005085146

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 溶液中での金ナノロッド組織体形成と2量体の分取2016

    • Author(s)
      蔦本 陽、新留 康郎
    • Organizer
      ナノ学会第14回大会
    • Place of Presentation
      北九州国際会議場(福岡県北九州市)
    • Year and Date
      2016-06-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] ポリマーメンブレン中の金ナノ粒子から金イオンの脱離イオン化2016

    • Author(s)
      新留 康郎、向 大輝
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      同志社大学(京都府京田辺市)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 極性有機溶媒中に分散する銀シェル金ナノロッドの調製2016

    • Author(s)
      北村 雄春、新留 康郎
    • Organizer
      ナノ学会第14回大会
    • Place of Presentation
      北九州国際会議場(福岡県北九州市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Mass spectrometry of gold ions desorbed from gold nanoparticles2016

    • Author(s)
      Yasuo Niidome
    • Organizer
      4th International Kyushu Colloid Colloquium
    • Place of Presentation
      九州大学西新プラザ(福岡県福岡市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Preparation of Gold Nanorod Assemblies and Separation of Nanorod Dimers by Sucrose Gradient Centrifugation2016

    • Author(s)
      Yo Tsutamoto、Hironobu Tahara、Masanori Kasai、Yasuro Niidome
    • Organizer
      4th International Kyushu Colloid Colloquium
    • Place of Presentation
      九州大学西新プラザ(福岡県福岡市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Assembling of Gold Nanorods and Separation of Nanorod Dimers2016

    • Author(s)
      Yo Tsutamoto、Yasuro Niidome
    • Organizer
      Joint Symposium of JTBW2016 & KNJS2016
    • Place of Presentation
      鹿児島大学(鹿児島県鹿児島市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Colloidal dispersion of rod shaped particles in polar organic solvents2016

    • Author(s)
      Takeharu Kitamura、Yasuro Niidome
    • Organizer
      Joint Symposium of JTBW2016 & KNJS2016
    • Place of Presentation
      鹿児島大学(鹿児島県鹿児島市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Gold Nanorods as a Mass Probe: Imaging Mass Spectrometry of Gold Ions Desorbed from Tissue Section2015

    • Author(s)
      Yasuro Niidome、Daiki Muko、Masanori Fujii、Takuro Niidome
    • Organizer
      6th Asian Conference on Colloid and Interface Science (ACCIS 2015)
    • Place of Presentation
      アルカス佐世保(長崎県佐世保市)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Gold-Silver Core-Shell Nanorods cast on a Plate: Aggregation and Orientation Depending on Surface Modification of a Plate2015

    • Author(s)
      Takeharu Kitamura、Tomomi Kikuta、Yasuro Niidome
    • Organizer
      6th Asian Conference on Colloid and Interface Science (ACCIS 2015)
    • Place of Presentation
      アルカス佐世保(長崎県佐世保市)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Imaging Mass Spectrometry of Gold Nanoparticles in Blotting Membranes and Tissue Sections2015

    • Author(s)
      Daiki Muko、Yuki Inoue、Takuro Niidome、Yasuro Niidome
    • Organizer
      6th Asian Conference on Colloid and Interface Science (ACCIS 2015)
    • Place of Presentation
      アルカス佐世保(長崎県佐世保市)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Colloidal Gold Nanoparticles Prepared in Hexadecyltrimethylammonium Bromide/Chloride Solutions2015

    • Author(s)
      Yuki Inoue、Yo Tsutamoto、Yasuro Niidome
    • Organizer
      6th Asian Conference on Colloid and Interface Science (ACCIS 2015)
    • Place of Presentation
      アルカス佐世保(長崎県佐世保市)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mass Spectrometry of Gold Colloids in Tissue Sections and Blotting Membranes2015

    • Author(s)
      Yasuro Niidome、Daiki Muko、Masanori Fujii
    • Organizer
      West Pacific Colloid Meeting 2015 (WPC2015)
    • Place of Presentation
      Siem Reap, Cambodia
    • Year and Date
      2015-11-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mapping of Gold Nanorods in a Liver Tissue Sections using Imaging Mass Spectrometry2015

    • Author(s)
      Yasuro Niidome、Masanori Fujii、Yuki Inoue、Daiki Muko、Takuro Niidome
    • Organizer
      Gold 2015
    • Place of Presentation
      Cardiff, UK
    • Year and Date
      2015-07-26
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 組織切片中に分布した金ナノロッドのイメージング質量分析2015

    • Author(s)
      新留 康郎、藤井 政徳、向 大輝、井上 雄貴、蔦本 陽、中嶋 直敏
    • Organizer
      第75回分析化学討論会
    • Place of Presentation
      山梨大学(山梨県甲府市)
    • Year and Date
      2015-05-23
    • Related Report
      2015 Research-status Report
  • [Presentation] カチオン性表面を有する球状金ナノ粒子の調製2015

    • Author(s)
      蔦本 陽、井上 雄貴、向 大輝、新留 康郎
    • Organizer
      ナノ学会第13回大会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-05-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 基板上にキャストした銀シェル金ナノロッドの分光特性2015

    • Author(s)
      新留 康郎、菊田 朝美、北村 雄春
    • Organizer
      ナノ学会第13回大会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-05-12
    • Related Report
      2015 Research-status Report
  • [Remarks] nanorod.net

    • URL

      http://www.nanorod.net

    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 水生生物用標識剤及び水生生物水生生物の標識方法2016

    • Inventor(s)
      新留康郎
    • Industrial Property Rights Holder
      新留康郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-235699
    • Filing Date
      2016-12-05
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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