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Development of processing technique for micro capsule as magnetic hypothermia implant

Research Project

Project/Area Number 15K13851
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Production engineering/Processing studies
Research InstitutionNara National College of Technology

Principal Investigator

Taniguchi Yukinori  奈良工業高等専門学校, 機械工学科, 准教授 (10413816)

Research Collaborator KODAMA Kenji  
KUNIYASU Hiroki  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords磁気温熱治療法 / QOL / 粉末成形 / 数値解析 / 絞り加工 / 個別要素法 / マイクロフォーミング
Outline of Final Research Achievements

Titanium micro capsule included Fe powder as an implant pellet for magnetic hyperthermia cancer care can be fabricated by newly suggested micro indent-extrusion process. Fe powder was sandwiched between two pieces of Ti thin sheet as a sheet / powder / sheet multi layered blank to fabricate micro capsule. To enhance the hysteresis loss of the capsule in alternating magnetic field, the powders was pulverized and induced strong strain by a planetary ball mill. In the capsulation process, the multi layered blank is placed freely on the die, and is extruded into a die cavity as the punch is indented on upper Ti blank. Since Fe powder layer works as a pressure transmission media, lower Ti thin sheet bulges into die cavity with Fe powder particles, and capsulation can be achievable. In order to discuss a feasibility of suggested process, we have proposed micro indent-extrusion test of Fe powder layer with Ti thin sheet to achieve capsulation of Fe powder and to fabricate implant pellet.

Academic Significance and Societal Importance of the Research Achievements

人体に無害なチタンをカプセル状に加工するとともに,その内部に外部からの磁気で発熱する金属粉を入れたこの世にないインプラントを作成する加工技術を開発した.カテーテルや注射針で患部に挿入することで開腹手術が不要になる.そのために0.8mm径以下とする必要があり,難加工のチタンをそのようなサイズにする極めて難しい精密金属加工技術にチャレンジした.温熱治療は副作用のない安全安心な治療法であり着目されている反面,現状では極めて高価な設備であり普及が進んでいない.本研究で開発したインプラントを活用すれば安価な外部交流磁場装置にて温熱治療が実現されると期待される.

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2019 2018 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (11 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results)

  • [Journal Article] Estimation of Yield Surface on Iron Powder Compaction for Finite Element Analysis using Drucker-Prager Cap Model2019

    • Author(s)
      R Ogawa, T Yoshimura, N Yagi, K Mizuta and Y Taniguchi
    • Journal Title

      IOP Conf. Series: Materials Science and Engineering

      Volume: 501 Pages: 1-8

    • DOI

      10.1088/1757-899x/501/1/012021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Simulation of Cutting Behavior in Green Powder Compact by using Distinct Element Method2018

    • Author(s)
      谷口 幸典,八木 直輝,大前 雄也,水田 航平
    • Organizer
      2018 World Congress on Powder Metallurgy, Beijing
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 鉄圧粉体の破壊挙動とそのDEM解析2018

    • Author(s)
      水田航平, 谷口幸典
    • Organizer
      粉体粉末冶金協会講演大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 鉄粉末圧粉体のせん断破壊特性2018

    • Author(s)
      吉村太智, 水田航平, 谷口幸典
    • Organizer
      粉体粉末冶金協会講演大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Drucker‐Prager Capモデルを用いた圧粉成形シミュレーション2018

    • Author(s)
      水田航平, 吉村太智, 小川椋太郎, 谷口幸典
    • Organizer
      塑性加工連合講演会講演論文集
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mechanism of Powder Assisted Deep Drawing of Ti thin sheet to fabricate small capsule implant2017

    • Author(s)
      K.Nishitani, K.Kodama, Y.Miki, M.Asano, M.Ozaki, H.Shimada, R.Fukuda and Y.Taniguchi
    • Organizer
      The 4th International Conference on Powder Metallurgy in Asia
    • Place of Presentation
      Sheraton Hsinchu Hotel, Hsinchu, TAIWAN
    • Year and Date
      2017-04-09
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mechanism of Powder assisted Deep Drawing of Ti thin sheet to fabricate small capsule implant2017

    • Author(s)
      Keigo Nishitani, Kohei Mizuta, Hirotsugu Shimada, Ryuichi Fukuda, Mitsunori Ozaki, Kenji Kodama and Yukinori Taniguchi
    • Organizer
      The 4th International Conference on Powder Metallurgy in Asia
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mechanism on Micro Deep Drawing Process of Ti through the Medium of Iron Powder2016

    • Author(s)
      Keigo Nishitani, Kohei Mizuta, Hirotsugu Shimada, Ryuichi Fukuda, Mitsunori Ozaki, Kenji Kodama and Yukinori Taniguchi
    • Organizer
      18th International Conference on Mechanical Engineering Design and Analysis
    • Place of Presentation
      Hyatt Regency, Osaka
    • Year and Date
      2016-10-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 定圧一面せん断試験による鉄粉末のせん断破壊挙動の実測―第2報 粉末粒子径の影響―2016

    • Author(s)
      谷口幸典, 潮田昂士, 西谷啓吾
    • Organizer
      平成28年塑性加工春季講演会講演論文集pp.175-176.
    • Place of Presentation
      京都工芸繊維大学松ヶ崎キャンパス
    • Year and Date
      2016-05-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 鉄粉末を媒介したTi箔の絞り加工による微細粉末カプセルの作成―第2報 絞り深さに及ぼす加工条件の評価―2016

    • Author(s)
      西谷啓吾,児玉謙司, 尾崎充紀, 島田大嗣, 三木 靖浩, 浅野 誠, 谷口 幸典
    • Organizer
      平成28年度塑性加工春季講演会
    • Place of Presentation
      京都工芸繊維大学松ヶ崎キャンパス
    • Year and Date
      2016-05-20
    • Related Report
      2015 Research-status Report
  • [Presentation] Micro Deep Drawing Process of Ti through the Medium of Iron Powder for Magnetic Hyperthermia Cancer Care2015

    • Author(s)
      Yukinori Taniguchi, Keigo Nishitani and Kenji Kodama
    • Organizer
      The 6th TSME International Conference on Mechanical Engineering
    • Place of Presentation
      Regent Cha-Am, Phetchaburi, Thailand
    • Year and Date
      2015-12-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 鉄粉末を内包したチタンカプセルインプラントの作製2015

    • Author(s)
      谷口幸典, 潮田昂士, 児玉謙司, 尾崎充紀, 西谷啓吾, 島田大嗣
    • Organizer
      第66回塑性加工連合講演会
    • Place of Presentation
      いわき市文化センター
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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