| Project/Area Number |
15K14204
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉本 誠 山口大学, 大学院創成科学研究科, 准教授 (80322246)
岡本 行広 大阪大学, 基礎工学研究科, 准教授 (50503918)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 自己組織系 / キラル分離 / クロマト担体 / 誘電緩和 / リポソーム膜 / アミノ酸 / 医薬品 / リポソーム / 自己組織化 / 膜ゆらぎ / キラル / 分離デバイス |
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| Outline of Final Research Achievements |
We have established a novel separation and/or analysis method based on chiral recognition function of liposome membrane. First, we developed the method to control the multiple interactions (via hydrophobic interaction, electrostatic interaction, hydrogen bonds) at the asymmetric carbon around the highly-ordered region on the liposome membrane surface by designing the membrane surface. Based on these results, we finally proposed a strategy to develop new types of chromatographic or electrophoretic techniques by utilizing the liposome-immobilized matrix or hierarchical support including self-assembled surface under the external control factors (i.e. heat, AC field etc.).
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