Development of neuronal birthdate tagging
| Project/Area Number |
15K14323
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
Hirata Tatsumi 国立遺伝学研究所, 総合遺伝研究系, 教授 (80260587)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 誕生日タグ / トランスジェニックマウス / 新規技術 / 神経発生 / 脳科学 / 誕生日タグづけ / マウス / 神経系 / 誕生日タグづけシステム / 神経回路 |
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| Outline of Final Research Achievements |
Birth timing of neurons determines many characteristics in neurons and has been used for classification of neurons. This study developed transgenic mouse lines in which post-mitotic neurons can be genetically tagged in a birthdate-dependent manner. Four useful transgenic lines were selected and characterized in detail. Our results suggested that these lines can be used as powerful resource for neuronal classification and subsequent manipulation of the classified neuronal subset.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Reallocation of olfactory Cajal-Retzius cells shapes neocortex architecture.2016
Author(s)
de Frutos CA, Bouvier G, Arai Y, Thion MS, Lokmane L, Maryama K, Garcia-Dominguez M, Charnay P, Hirata T, Riethmacher D, Grove EA, Tissir F, Casado M, Pierani A, and Garel S
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Journal Title
Neuron
Volume: 92
Pages: 435-448
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Telomere Visualization in Tissue Sections Using Pyrrole-Imidazole Polyamide Probes.2016
Author(s)
Sasaki, A., Ide, S., Kawamoto, Y., Bando, T., Murata, Y., Shimura, M., Yamada, K., Hirata, A., Nokihara, K., Hirata, T., Sugiyama, H., Maeshima, K.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 29261-29261
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain2015
Author(s)
Shigeaki Kanatani, Takao Honda, Michihiko Aramaki, Kanehiro Hayashi, Ken-ichiro Kubo, Mami Ishida, Daisuke H. Tanaka, Takeshi Kawauchi, Katsutoshi Sekine, Sayaka Kusuzawa, Takahiko Kawasaki, Tatsumi Hirata, Hidenori Tabata, Per Uhlen and Kazunori Nakajima
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Journal Title
Proceedings of the National Academy of Sciences of the United States of America
Volume: 112(36)
Issue: 36
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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