• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of ATLL-associated genes in Rapid ATLL model mouse

Research Project

Project/Area Number 15K14388
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

Saito Masumichi  国立感染症研究所, 血液・安全性研究部, 主任研究官 (20571045)

Co-Investigator(Kenkyū-buntansha) 日吉 真照  国立感染症研究所, 血液・安全性研究部, 主任研究官 (40448519)
Co-Investigator(Renkei-kenkyūsha) HIDEKATSU Iha  大分大学, 医学部, 准教授 (50242631)
HIROO Hasegawa  長崎大学, 医学部, 准教授 (00398166)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords実験動物モデル / 実験動物 / ATL発症原因遺伝子 / HTLV-1 / ATLL / マウスモデル
Outline of Final Research Achievements

In ATLL model mouse, we found that point mutations and 5’deletions of HTLV-1 induce HBZ activation. Furthermore, the HBZ activation mechanism on HTLV-1 carrying the deletion was due to disruption of mir-324-3P mediated HBZ repression. Interestingly, we also found that mir-324-3P was deleted in about 40% of ATLL cases. This result strongly suggests that mir-324-3P might function as a tumor suppressor gene in the process of ATLL development

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] コロンビア大学/スローンケタリングメモリアルホスピタル(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] コロンビア大学(米国)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] Memorial Sloan Kettering Cancer Center(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Proviral features of human T cell leukemia virus type 1 in carriers with indeterminate western blot analysis results.2017

    • Author(s)
      Kuramitsu M, Sekizuka T, Yamochi T, Firouzi S, Sato T, Umeki K, Sasaki D, Hasegawa H, Kubota R, Sobata R, Matsumoto C, Kaneko N, Momose H, Araki K, Saito M, Nosaka K, Utsunomiya A, Koh K, Ogata M, Uchimaru K, Iwanaga M, Sagara Y, Yamano Y, et al.
    • Journal Title

      J Clin Microbiol.

      Volume: 55(9) Issue: 9 Pages: 2838-2849

    • DOI

      10.1128/jcm.00659-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 成人T細胞白血病・リンパ腫患者におけるHTLV-1/EBV共感染B細胞の存在意義2017

    • Author(s)
      斎藤益満、伊波英克、長谷川寛雄、他35名
    • Organizer
      4第回日本HTLV-1学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 成人T細胞白血病・リンパ腫におけるHBZ活性化 - miR-324-3PによるHBZ発現抑制の崩壊 -2017

    • Author(s)
      松橋一彦、斎藤益満、他19名
    • Organizer
      4第回日本HTLV-1学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒトT細胞白血病ウイルス1型変異を介した非ホジキンリンパ腫 発症リスク評価・判定法の開発2017

    • Author(s)
      斎藤益満
    • Organizer
      TOBIRA第6回研究交流フォーラム
    • Place of Presentation
      ソラシティカンファレンスセンター ソラシティホール
    • Related Report
      2016 Research-status Report
    • Invited
  • [Patent(Industrial Property Rights)] 非ホジキンリンパ腫発症のリスク判定補助方法2016

    • Inventor(s)
      斎藤益満、伊波英克、長谷川寛雄
    • Industrial Property Rights Holder
      斎藤益満、伊波英克、長谷川寛雄
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-150300
    • Filing Date
      2016-07-29
    • Acquisition Date
      2016-08-05
    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2022-02-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi