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Development of the novel drug repositioning method based on disease genetics

Research Project

Project/Area Number 15K14429
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Medical genome science
Research InstitutionOsaka University (2016)
Tokyo Medical and Dental University (2015)

Principal Investigator

OKADA YUKINORI  大阪大学, 医学系研究科, 教授 (70727411)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords遺伝統計学 / ドラッグ・リポジショニング / ゲノム創薬
Outline of Final Research Achievements

In this study, we constructed an in silico analytical method that utilizes large scale human disease genome analysis results to efficiently identify novel therapeutic targets and candidates of drug repositioning. We collected drug and drug target gene information from multiple drug discovery databases. We also curated Anatomical Therapeutic Chemical (ATC) Classification System to list disease and approved drug lists. By applying the newly constructed method to the latest disease genetics study results of multiple human diseases including metabolic diseases, we empirically evaluated the value of our method.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (11 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 11 results,  Open Access: 11 results,  Acknowledgement Compliant: 4 results)

  • [Int'l Joint Research] Harvard Medical School/Broad Institute(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Sanger Institute(英国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1.2016

    • Author(s)
      Li G, Cunin P, Wu D, Diogo D, Yang Y, Okada Y, Plenge RM, Nigrovic PA
    • Journal Title

      PLoS Genet

      Volume: 12 Issue: 9 Pages: e1006292-e1006292

    • DOI

      10.1371/journal.pgen.1006292

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity.2016

    • Author(s)
      Mahajan A, Rodan AR, Le TH, Gaulton KJ, Haessler J, ..., Okada Y, Laurie CC, Morris AP, Franceschini N
    • Journal Title

      Am J Hum Gen

      Volume: 99 Issue: 3 Pages: 636-646

    • DOI

      10.1016/j.ajhg.2016.07.012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.2016

    • Author(s)
      Shiraishi K, Okada Y 他44名 Inazawa J 38番目
    • Journal Title

      Nat Commun.

      Volume: 7 Issue: 1 Pages: 12451-12451

    • DOI

      10.1038/ncomms12451

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis2016

    • Author(s)
      Okada Y, Suzuki A, Ikari K, Terao C, Kochi Y, Ohmura K, Higasa K, Akiyama M, Ashikawa K, Kanai M, Hirata J, Suita N, Teo YY, Xu H, Bae SC, Takahashi A, Momozawa Y, Matsuda K, Momohara S, Taniguchi A, Yamada R, Mimori T, Kubo M, Brown MA, Raychaudhuri S, Matsuda F, Yamanaka H, Kamatani Y, Yamamoto K
    • Journal Title

      Am J Hum Genet

      Volume: 99 Issue: 2 Pages: 366-374

    • DOI

      10.1016/j.ajhg.2016.06.019

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study.2016

    • Author(s)
      Li Z, Xia Y, Feng LN, Chen JR, Li HM, Cui J, Cai QQ, Sim KS, ..., Okada Y, Raychaudhuri S, Lim ST, Tan W, Peng RJ, Khor CC, Bei JX
    • Journal Title

      Lancet Oncol

      Volume: 17 Issue: 9 Pages: 1240-1247

    • DOI

      10.1016/s1470-2045(16)30148-6

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Empirical estimation of genome-wide significance thresholds based on the 1000 Genomes Project data set2016

    • Author(s)
      Kanai M, Tanaka T, Okada Y
    • Journal Title

      J Hum Genet

      Volume: 61 Issue: 10 Pages: 861-866

    • DOI

      10.1038/jhg.2016.72

    • NAID

      40020966136

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Systematic analysis of mutation distribution in three dimensional protein structures identifies cancer driver genes2016

    • Author(s)
      Fujimoto A, Okada Y, Boroevich KA, Tsunoda T, Taniguchi H, Nakagawa H
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 26483-26483

    • DOI

      10.1038/srep26483

    • NAID

      120005774574

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significant impact of miRNA-target gene networks on genetics of human complex traits.2016

    • Author(s)
      Okada Y, Muramatsu T, Suita N, Kanai M, Kawakami E et al.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 22223-22223

    • DOI

      10.1038/srep22223

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry2016

    • Author(s)
      76.Imamura M, Takahashi A, Yamauchi T, Hara K, Yasuda K, ... Okada Y et al.
    • Journal Title

      Nat Genet

      Volume: 48 Issue: 3 Pages: 323-330

    • DOI

      10.1038/ng.3496

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ethnically shared and heterogeneous impacts of molecular pathways suggested by the genome-wide meta-analysis of rheumatoid arthritis.2016

    • Author(s)
      Okada Y, Raj T, Yamamoto K.
    • Journal Title

      Rheumatology

      Volume: 22 Issue: 1 Pages: 186-189

    • DOI

      10.1093/rheumatology/kev314

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Construction of a population-specific HLA imputation reference panel and its application to Graves’ disease risk in Japanese.2015

    • Author(s)
      Okada Y, Momozawa Y, Ashikawa K, Kanai M, Matsuda K et al.
    • Journal Title

      Nat Genet

      Volume: 42 Issue: 7 Pages: 798-802

    • DOI

      10.1038/ng.3310

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research

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Published: 2015-04-16   Modified: 2022-02-16  

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