| Project/Area Number |
15K14735
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Kyushu University |
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Principal Investigator |
Sato Masao 九州大学, 農学研究院, 教授 (90294909)
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| Co-Investigator(Kenkyū-buntansha) |
城内 文吾 九州大学, 農学研究院, 助教 (00548018)
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| Research Collaborator |
MIYAGO Motonori
TANAKA Yasutake
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 認知症 / 糖尿病 / モデル動物 / 酸化コレステロール / ラット / βアミロイド / アルツハイマー / 糖代謝 / アミロイドβタンパク質 |
|---|
| Outline of Final Research Achievements |
Dementia is a neurodegenerative disorder in later life. Type 2 Diabetes (T2D) has been reported as a risk factor of dementia. Exogenously hypercholesterolemic (ExHC) rats, a model of diet-induced hypercholesterolemia, have lower learning ability than other strains. Our previous study showed that Smek2 is a responsible gene for the ExHC rat’s phenotypes. ExHC rats showed T2D-like glucose metabolic disorders, such as insulin resistance and hyperglycemia. Therefore, we hypothesized that ExHC rat is a model for AD related to T2D. In this study, we researched cerebral lipid and glucose metabolism. We researched cerebral metabolism in 22-week-old male ExHC and SD rats with no cholesterol diet for 2 weeks (old-exp). The cerebral cortical b-amiroid levels were significantly higher in ExHC rats than SD rats. These data suggest that ExHC rats have a risk of developing dementia.
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