Evaluation of a novel food function mechanism by the interspecies exosome crosstalk
| Project/Area Number |
15K14736
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ナノ粒子 / 抗炎症作用 / 種間相互作用 / 植物由来エクソソーム様ナノベシクル / 抗炎症 / 加工・調理 / タマネギ / ケルセチン / 腸管炎症 |
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| Outline of Final Research Achievements |
We have established the method for the preparation of nano-particle derived from fruits and vegetables. This particle consists of diverse lipids and proteins, and RNA and flavonoids were occurred in Allium cepa derived one. This particle suppressed inflammatory response in macrophage and flavonoids were not responsible for this effect. Heat treatment of this particle did not affect on the anti-inflammatory effect of particle. Three subfractions were recovered from Curcuma longa derived nano-particle and all of them were incorporated into the macrophages and showed anti-inflammatory effects.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Blueberry (<i>Vaccinium virgatum</i> Aiton) Leaf Infusion Ameliorates Insulin Resistance in Mice Fed a High-fat, High-sucrose Diet2015
Author(s)
Yamasaki M., Matsuyama Y., Hayasegawa R., Hamada K., Nishiyama K., Kai T., Kamenaga K., Arakawa T., Tari H., Shimizu Y., Matsuura Y., Yukizaki C.
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Journal Title
Food Science and Technology Research
Volume: 21
Issue: 6
Pages: 827-833
DOI
NAID
ISSN
1344-6606, 1881-3984
Related Report
Peer Reviewed
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