| Project/Area Number |
15K14840
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal production science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HAKUNO FUMIHIKO 東京大学, 大学院農学生命科学研究科, 助教 (30282700)
KATAOKA NAOYUKI 東京大学, 大学院農学生命科学研究科, 特任准教授 (60346062)
FUJII WATARU 東京大学, 大学院農学生命科学研究科, 助教 (40708161)
ITO AKIHIRO 独立行政法人理化学研究所, 吉田化学遺伝学研究室, 専任研究員 (40391859)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 代謝・内分泌制御 / インスリン受容体 / スプライシング / インスリン様シグナル / インスリン受容体基質 / 代謝・内分泌 / 増殖 / 代謝調節 |
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| Outline of Final Research Achievements |
Alternative splicing of insulin receptor (IR) of exon 11 encoding a part of the a-subunit results in the expression of two isoforms: IR-A (skipping exon 11) and IR-B (including exon 11). Our results demonstrated that alternative splicing of insulin receptor RNA is regulated in tissue-specific manners in response to environment changes through insulin receptor substrate-1, splicing regulatory factor PRMT5, and various splicing factors including RBFOX. We also found the differences of insulin-like signaling between IR-A and IR-B.
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