Establishment of method inducing DNA methylation by epigenome editing.
| Project/Area Number |
15K14924
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Kitasato University |
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Principal Investigator |
YAMAZAKI Taiga 北里大学, 北里大学メディカルセンター, 上級研究員 (90524231)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | DNAメチル化 / エピゲノム編集 / ペリセントロメア / セントロメア |
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| Outline of Final Research Achievements |
DNA methylation plays crucial roles in regulating gene expression, and aberrant DNA methylation leads developmental defects and diseases. Artificial control of DNA methylation in specific loci would be the valuable tool for both basic and applied research. In this research, we develop the method of epigenome editing especially in ‘Writing DNA methylation’ in mouse pericentromeres and centromeres.
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Report
(4 results)
Research Products
(8 results)
