| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
To investigate the role of hypusination, a post-translational modification specific to translation factor eIF5A, in translation, we identified several mRNA sequences whose product levels were affected by the presence or absence of hypusination. The fact that sequences whose translation require hypusination of eIF5A did not overlap with those identified as targets of eIF5A suggested that eIF5A alters target proteins according to its modification status.
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