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Study on metabolic shift regulated by translation factor

Research Project

Project/Area Number 15K14925
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied molecular and cellular biology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Matsuyama Akihisa  国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 (90399444)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords翻訳 / 翻訳制御 / エネルギー代謝
Outline of Final Research Achievements

To investigate the role of hypusination, a post-translational modification specific to translation factor eIF5A, in translation, we identified several mRNA sequences whose product levels were affected by the presence or absence of hypusination. The fact that sequences whose translation require hypusination of eIF5A did not overlap with those identified as targets of eIF5A suggested that eIF5A alters target proteins according to its modification status.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Preparation of Cell Lysates of Fission Yeast for Immunoprecipitation.2018

    • Author(s)
      Akihisa Matsuyama, Atsuko Shirai, Minoru Yoshida
    • Journal Title

      Methods in Molecular Biology

      Volume: 1721 Pages: 125-133

    • DOI

      10.1007/978-1-4939-7546-4_12

    • ISBN
      9781493975457, 9781493975464
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] The role of eIF5A and its post-translational modifications in protein translation2017

    • Author(s)
      Hilbert Magpantay, Naoko Kondo, Akihisa Matsuyama, Minoru Yoshida
    • Organizer
      Pombe2017 9th International fission yeast meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel mechanism regulating metabolic switch from aerobic to anaerobic respiration2016

    • Author(s)
      Akihisa Matsuyama
    • Organizer
      Frontiers in aging research toward healthy longevity
    • Place of Presentation
      丸の内MY PLAZAホール(東京都千代田区)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 翻訳因子eIF5Aによるエネルギー代謝制御2016

    • Author(s)
      近藤 直子、白井 温子、松山 晃久、夏目 徹、堂前 直、浜本 牧子、吉田 稔
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] A role of eIF5A hypusination on an oxygen-dependent metabolic shift2015

    • Author(s)
      Kondo N, Shirai A, Matsuyama A, Natsume T, Hamamoto M, Yoshida M
    • Organizer
      8th International fission yeast meeting
    • Place of Presentation
      神戸市
    • Year and Date
      2015-06-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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