| Project/Area Number |
15K14926
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KUMADA Kanako 東北大学, 大学院薬学研究科, 助手 (30748504)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 有機超電子供与剤 / 還元反応 / 金属フリー / 芳香族 / 選択的分子変換 / アゾベンゼン / 複素環化合物 / 炭素アニオン / 有機超電子供与体 / 電子移動 / 官能基変換 / 分子変換 / 還元 |
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| Outline of Final Research Achievements |
Metal free selective transformation of aromatic halides using organic super electron donor(SED) was investigated. Two types of SED were emplyed, and one was derived from N-methylbenzimidazole and the other was derived from 4-dimethylpyridine. Using these SEDs transformation of aromatic and heteroaromatic compounds with functional groups were examined. Especially, cylization using itramolecular nucleophilic reaction was investigated and selective transforming reactions were performed in the presence of various electrophilic functionalities, which have not easily achieved by organometallic methodologies. During the investigation, it was also found that the reaction of nitrobenzenes with SED gave azobenzenes in one step in the presence of functional groups.
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