Construction of hiPS-based drug evaluation system for Alzheimer's disease
| Project/Area Number |
15K14962
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
Akaike Akinori 京都大学, 薬学研究科, 客員教授 (80135558)
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| Co-Investigator(Kenkyū-buntansha) |
泉 安彦 京都大学, 薬学研究科, 助教 (60456837)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ヒトiPS由来細胞 / アルツハイマー病 / 薬効評価 |
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| Outline of Final Research Achievements |
We investigated whether the mechanism of Aβ-induced neurotoxicity accumulated in rat cultured neurons applied to human neurons and aimed to construct human iPS-based drug evaluation system for Alzheimer's disease. First, iPS cells were differentiated into neural stem cells (NSCs), and we obtained hiPS-differentiated NSCs which were not requiring feeder cells. Next, we examined that effect of neuron-astrocyte interaction on cytotoxicity using rat neuron monoculture and rat neuron-astrocyte mixed culture. It is suggested that the interaction between neuron and astrocyte reduce the susceptibility to Aβ-induced neurotoxicity.
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] Effect of vitamin K2 on the anticoagulant activity of warfarin during the perioperative period of catheter ablation: Population analysis of retrospective clinical data.2016
Author(s)
Zhou, Zhi; Yano, Ikuko; Odaka, Sumiko; Morita, Yosuke; Shizuta, Satoshi; Hayano, Mamoru; Kimura, Takeshi; Akaike, Akinori; Inui, Ken-ichi; Matsubara, Kazuo
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Journal Title
J Pharm Health Care Sci.
Volume: 2
Issue: 1
Pages: 17-17
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] 10-Oxo-trans-11-octadecenoic acid generated from linoleic acid by a gut lactic acid bacterium Lactobacillus plantarum is cytoprotective against oxidative stress2016
Author(s)
Furumoto, H., T. Nanthirudjanar, T. Kume, Y. Izumi, S.B. Park, N. Kitamura, S. Kishino, J. Ogawa, T. Hirata, T. Sugawara
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Journal Title
Toxicol. Appl. Pharmacol.
Volume: 296
Pages: 1-9
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Compensatory role of the Nrf2-ARE pathway against paraquat toxicity: Relevance of 26S proteasome activity2015
Author(s)
Izumi, Y., Yamamoto, N., Matsushima, S., Yamamoto, T., Takada-Takatori, Y., Akaike, A., and Kume, T
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Journal Title
J. Pharmacol Sci.
Volume: 129
Issue: 3
Pages: 150-159
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] Hypoxia-reoxygenation Induces Brain Ischemia-reperfusion, Resulting in Neuronal Damage in Zebrafish Larva.2015
Author(s)
Sawahata, M., Miyamoto, M., Takemasa, S., Kawamoto, T., Izumi, Y., Akaike, A. and Kume, T.
Organizer
第21回小型魚類研究会
Place of Presentation
大阪大学 銀杏会館（Osaka）
Year and Date
2015-09-20
Related Report
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