Control of epigenetics by chemical modulator based on natural products
| Project/Area Number |
15K14974
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | エピジェネティックス / 創薬化学 / 抗がん剤 / 有機化学 / エピジェネテッィクス / 天然物 |
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| Outline of Final Research Achievements |
Analogues of DNA bisintercalating natural products were designed and synthesized and their DNA binding properties as well as cytotoxicity against human cancer cells were evaluated. Several analogues exhibit a potent cytotoxicity against a panel of human cancer cells with nM level and some of the analogues also show in vivo antitumor activity in the experiments using mouse xenograft model. As a result, we were able to find a promising anticancer lead compound.
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Report
(3 results)
Research Products
(18 results)
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[Presentation] Synthetic study of plusbacin A32015
Author(s)
Katsuyama, A.; Matsuda, A.; Ichikawa, S.
Organizer
PACIFICHEM, The International Chemical Congress of Pacific Basin Societies 2015 (Poster Presentation)
Place of Presentation
Honolulu (Hawaii, USA)
Year and Date
2015-12-15
Related Report
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