| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
We analyzed the miRNA-SNPs in Japanese subjects targeting 1,900 pre-miRNAs to investigate whether there are ethnic differences in their allele frequencies, and to identify biomarkers, which are useful to predict adverse reactions of anti-cancer drugs or incidence of cancers. Approximately 150 miRNA-SNPs were found in a person on average for healthy subjects and cancer patients. We found several miRNA-SNPs whose frequencies were significantly different with in global populations, suggesting ethnic differences. We identified miRNA-SNPs whose frequencies were different between healthy subjects and non-small cell lung cancer, colorectal cancer, or adult T-cell / leukemia patients. These miRNA-SNPs can be biomarkers of incidence of each cancer.
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