Medication for pregnant women based on 'barrier transition' behavior in feto-placental circulation
| Project/Area Number |
15K15007
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
Tomi Masatoshi 慶應義塾大学, 薬学部(芝共立), 教授 (30334717)
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| Co-Investigator(Kenkyū-buntansha) |
西村 友宏 慶應義塾大学, 薬学部(芝共立), 講師 (40453518)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 胎盤関門 / miRNA |
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| Outline of Final Research Achievements |
We have clarified the developmental change in the placental transporters such as glucose transporter 1 (GLUT1) and monocarboxylate transporter 1 (MCT1), while the expressions of ABC transporters such as MDR1 and BCRP were unchanged during pregnancy. We also found a placenta-derived miRNA which may work for maturation of both placental and blood-brain barrier. These observations are helpful for examining the interorgan network in the fetoplacental circulation for establishing and managing barriers in the placenta and the brain.
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Report
(3 results)
Research Products
(12 results)
