| Project/Area Number |
15K15011
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
下田 浩 弘前大学, 医学研究科, 教授 (20274748)
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| Co-Investigator(Renkei-kenkyūsha) |
MOROHASHI SATOKO 弘前大学, 大学院医学研究科, 助教 (90569592)
WU YUNYAN 弘前大学, 大学院医学研究科, 助教 (40636586)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 血管新生 / 腫瘍細胞 / 浸潤性増殖 / 血行性転移 / リンパ行性転移 |
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| Outline of Final Research Achievements |
Angiogenesis and stromal invasion play important roles in tumor growth/extension. We have identified angio-lymphatic vessels positive for both vascular marker (factor VIII) and lymphatic marker (D2-40). We examined histopathological characteristics of the aigio-lymphatic vessels in the tumors. The angio-lymphatic vessels are found not only tumor tissues, but also their surrounding tissues, and thought to play a significant role in early tumor invasion and neoangiogenesis.
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