Neuronal network analysis of hierarchical alteration in juveniles rat
Project/Area Number |
15K15041
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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Research Institution | National Center for Geriatrics and Gerontology |
Principal Investigator |
TADA Hirobumi 国立研究開発法人国立長寿医療研究センター, 統合加齢神経科学研究部, 室長 (20464993)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 優劣性交互関係 / 内側前頭前野 / 若年期 |
Outline of Final Research Achievements |
Individuals exposed early in life to social separation, one form of neglect, develop impaired interpersonal relationships, including aggressive behaviors and social hierarchy. Although there is evidence that functional circuits in the medial prefrontal cortex (mPFC) regulate social behaviors, the effect of social separation early in life on neural circuit development in the mPFC is not well understood. Here, we found the mPFC neural mechanisms that isolation of neonatal rats altered social hierarchy and aggression in juveniles.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Neonatal isolation augments social dominance by altering actin dynamics in the medial prefrontal cortex.2016
Author(s)
Tada H, Miyazaki T, Takemoto K, Takase K, Jitsuki S, Nakajima W, Koide M, Yamamoto N, Komiya K, Suyama K, Sano A, Taguchi A, Takahashi T
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Journal Title
Proc Natl Acad Sci U S A
Volume: 113
Issue: 45
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Modeling neurological diseases with induced pluripotent cells reprogrammed from immortalized lymphoblastoid cell lines.2016
Author(s)
Fujimori K, Tezuka T, Ishiura H, Mitsui J, Doi K, Yoshimura J, Tada H, Matsumoto T, Isoda M, Hashimoto R, Hattori N, Takahashi T, Morishita S, Tsuji S, Akamatsu W, Okano H.
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Journal Title
Mol Brain.
Volume: 9
Issue: 1
Pages: 88-88
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells2016
Author(s)
Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhou Z, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W, Okano H.
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Journal Title
Stem Cell Reports.
Volume: 6
Issue: 3
Pages: 422-35
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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