Neuronal network analysis of hierarchical alteration in juveniles rat

• Project/Area Number: 15K15041
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: TADA Hirobumi 国立研究開発法人国立長寿医療研究センター, 統合加齢神経科学研究部, 室長 (20464993)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 優劣性交互関係 / 内側前頭前野 / 若年期

Outline of Final Research Achievements

Individuals exposed early in life to social separation, one form of neglect, develop impaired interpersonal relationships, including aggressive behaviors and social hierarchy. Although there is evidence that functional circuits in the medial prefrontal cortex (mPFC) regulate social behaviors, the effect of social separation early in life on neural circuit development in the mPFC is not well understood. Here, we found the mPFC neural mechanisms that isolation of neonatal rats altered social hierarchy and aggression in juveniles.

Research Products

• [Journal Article] Optical inactivation of synaptic AMPA receptors erases fear memory. (2017)
  • Author(s): K. Takemoto, H. Iwanari, H. Tada, K. Suyama, A. Sano, T. Nagai, T. Hamakubo, T. Takahashi
  • Journal Title: Nat Biotechnol Volume: 35 Issue: 1 Pages: 38-47
  • DOI: 10.1038/nbt.3710
  • Peer Reviewed / Open Access
• [Journal Article] 特集 記憶ふたたび 10.ストレスと認知機能 (2016)
  • Author(s): 多田敬典、高橋琢哉
  • Journal Title: 生体の科学 Volume: 67 Issue: 1 Pages: 47-50
  • DOI: 10.11477/mf.2425200397
  • ISSN: 0370-9531, 1883-5503
  • Year and Date: 2016-02-15
• [Journal Article] Neonatal isolation augments social dominance by altering actin dynamics in the medial prefrontal cortex. (2016)
  • Author(s): Tada H, Miyazaki T, Takemoto K, Takase K, Jitsuki S, Nakajima W, Koide M, Yamamoto N, Komiya K, Suyama K, Sano A, Taguchi A, Takahashi T
  • Journal Title: Proc Natl Acad Sci U S A Volume: 113 Issue: 45
  • DOI: 10.1073/pnas.1606351113
  • Peer Reviewed / Open Access
• [Journal Article] Modeling neurological diseases with induced pluripotent cells reprogrammed from immortalized lymphoblastoid cell lines. (2016)
  • Author(s): Fujimori K, Tezuka T, Ishiura H, Mitsui J, Doi K, Yoshimura J, Tada H, Matsumoto T, Isoda M, Hashimoto R, Hattori N, Takahashi T, Morishita S, Tsuji S, Akamatsu W, Okano H.
  • Journal Title: Mol Brain. Volume: 9 Issue: 1 Pages: 88-88
  • DOI: 10.1186/s13041-016-0267-6
  • Peer Reviewed / Open Access
• [Journal Article] 糖代謝シグナルを介した認知機能制御機構 (2016)
  • Author(s): 多田敬典、徳永暁憲、田之頭大輔、倉田栄子、田口明子
  • Journal Title: 基礎老年研究誌 Volume: 40 Pages: 9-14
  • Peer Reviewed
• [Journal Article] Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells (2016)
  • Author(s): Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhou Z, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W, Okano H.
  • Journal Title: Stem Cell Reports. Volume: 6 Issue: 3 Pages: 422-35
  • DOI: 10.1016/j.stemcr.2016.01.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nogo Receptor Signaling Restricts Adult Neural Plasticity by Limiting Synaptic AMPA Receptor Delivery. (2016)
  • Author(s): Jitsuki S, Nakajima W, Takemoto K, Sano A, Tada H, Takahashi-Jitsuki A, Takahashi T
  • Journal Title: Cerebral cortex Volume: 26(1) Issue: 1 Pages: 427-439
  • DOI: 10.1093/cercor/bhv232
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Estrous Cycle-Dependent Phasic Changes in the Stoichiometry of Hippocampal Synaptic AMPA Receptors in Rats (2015)
  • Author(s): Tada H, Koide M, Ara W, Shibata Y, Funabashi T, Suyama K, Goto T, Takahashi T.
  • Journal Title: PLoS One Volume: 10 Issue: 6 Pages: e0131359-e0131359
  • DOI: 10.1371/journal.pone.0131359
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 糖代謝シグナル異常を介したシナプスを起点とする認知機能障害機構の解明 (2017)
  • Author(s): 多田敬典、徳永暁憲、田之頭大輔、柏田舞波、佐治多美子、田口明子
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: 浜松
  • Year and Date: 2017-03-29
• [Presentation] 糖尿病に伴う認知機能障害における前頭葉・海馬神経ネットワーク制御機構の解析 (2017)
  • Author(s): 多田敬典、徳永暁憲、田之頭大輔、佐治多美子、柏田舞波、田口明子
  • Organizer: 第31回日本糖尿病・肥満動物学会年次学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2017-02-10
• [Presentation] アルツハイマー病発症における海馬IRS2シグナルの関与 (2017)
  • Author(s): 田之頭大輔, 徳永暁憲, 多田敬典, 柏田舞波, 佐治多美子, 田口明子
  • Organizer: 日本糖尿病・肥満動物学会年次学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2017-02-10
• [Presentation] 糖尿病随伴認知機能障害の発症過程における海馬インスリン様シグナルの変容 (2017)
  • Author(s): 徳永暁憲、多田敬典、田之頭大輔、佐治多美子、柏田舞波、田口明子
  • Organizer: 日本糖尿病・肥満動物学会年次学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2017-02-10
• [Presentation] 糖尿病に伴う認知機能低下と海馬IRS2シグナルとの関連 (2016)
  • Author(s): 田之頭大輔、福岡屋航、川邉健士朗、徳永暁憲、多田敬典、柏田舞波、佐治多美子、倉田栄子、田口明子
  • Organizer: 第35回認知症学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-12-01
• [Presentation] 低養育環境ストレスによる若年期優劣関係に影響を及ぼす内側前頭前野分子メカニズムの解明 (2016)
  • Author(s): 多田敬典、高橋琢哉
  • Organizer: 第58回日本神経化学会大会
  • Place of Presentation: 大宮ソニックシティ・さいたま市
  • Year and Date: 2016-09-12
• [Presentation] 若年期優劣関係を決定する分子メカニズムの解明 (2016)
  • Author(s): 多田敬典、高橋琢哉
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター・札幌市
  • Year and Date: 2016-03-24
• [Presentation] Hippocampal insulin-like-signaling induces impairment of cognitive function and adult neurogenesis in diabetic model mice. (2016)
  • Author(s): Tada H, Tokunaga A, Fukuokaya W, Kurata E, Taguchi A
  • Organizer: 8th NAGOYA Global Retreat
  • Place of Presentation: あいち健康の森プラザ・大府市
  • Year and Date: 2016-02-12
• [Presentation] Neonatal isolation augments social dominance by altering actin dynamics in the medial prefrontal cortex (2015)
  • Author(s): Tada H, Suyama K, Takahashi T.
  • Organizer: Neuroscience2015
  • Place of Presentation: 神戸国際会議場・神戸市
  • Year and Date: 2015-07-29
• [Presentation] Estrous Cycle-Dependent Phasic Changes in the Stoichiometry of Hippocampal Synaptic AMPA Receptors in Rats (2015)
  • Author(s): Koide M, Tada H, Ara W, Shibata S, Funabashi T, Suyama K, Goto T, Takahashi T.
  • Organizer: Neuroscience2015
  • Place of Presentation: 神戸国際会議場・神戸市
  • Year and Date: 2015-07-29