Elucidation of a novel mechanism for maintenance of multipotency in adult multipotent stem cells
Project/Area Number |
15K15059
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
General medical chemistry
|
Research Institution | Akita University (2016-2017) Tohoku University (2015) |
Principal Investigator |
Akashi Hideo 秋田大学, 医学(系)研究科(研究院), 助教 (10431785)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
Keywords | 成体幹細胞 / 分化誘導 / 神経細胞 / スプライシング / 多能性 |
Outline of Final Research Achievements |
Maintenance of Multipotency in adult stem cells is regulated by a mechanism different from that of embryonic stem cells. We identified a gene region involved in maintenance of multipotency and direction of differentiation. Furthermore, we indicated the genes induced neuron-specific expression and splicing. These results might lead to development of a novel method to produce neurons from adult stem cells.
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Report
(4 results)
Research Products
(7 results)