Functional analysis of epigenetic factors that inhibit cellular senescence
| Project/Area Number |
15K15068
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 細胞老化 / エピゲノム / 遺伝子 / 代謝 |
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| Outline of Final Research Achievements |
Gene regulation and epigenomic conversion are involved in the program of cellular senescence, but the molecular mechanisms remain unclear. We investigated the key processes of cellular senescence, using specific siRNAs libraries against nuclear and chromatin factors, and found that 1) retinoblastoma protein promotes oxidative phosphorylation through up-regulation of glycolytic genes in oncogene-induced senescent cells; 2) the SETD8/PR-Set7 methyltransferase functions as a barrier to prevent senescence-associated metabolic remodeling.
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] The SETD8/PR-Set7 Methyltransferase Functions as a Barrier to Prevent Senescence-Associated Metabolic Remodeling.2017
Author(s)
Tanaka, H., Takebayashi S. I., Sakamoto, A., Igata, T., Nakatsu, Y., Saitoh, N., Hino, S., and Nakao, M.
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Journal Title
Cell Rep.
Volume: 18
Issue: 9
Pages: 2148-2161
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Roles of long non-coding RNAs in chromosome domains2016
Author(s)
Tomita, S., Abdalla, M. O. A., Fujiwara, S., Yamamoto, T., Iwase, H., Nakao, M. and Saitoh, N.*.
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Journal Title
WIREs RNA
Volume: -
Issue: 2
Pages: 30366-30374
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Lysine-specific demethylase-1 contributes to malignant behavior by regulation of invasive activity and metabolic shift in esophageal cancer2016
Author(s)
Kosumi K, Baba Y, Sakamoto Y, Ishimoto T, Harada K, Nakamura K, Kurashige J, Hiyoshi Y, Iwatsuki M, Iwagami S, Sakamoto Y, Miyamoto Y, Yoshida N, Oki E, Watanabe M, Hino S, Nakao M, Baba H
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Journal Title
Int J Cancer
Volume: 138
Issue: 2
Pages: 428-39
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome2016
Author(s)
Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M, Fukuda A, Nosaka K, Watanabe T, Rowan A, Nakao M, and Bangham CRM.
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Journal Title
PNAS
Volume: in press
Issue: 11
Pages: 3054-3059
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The actin family protein ARP6 contributes to the structure and the function of the nucleolus2015
Author(s)
Kitamura, H., Matsumori, H., Kalendova, A., Hozak, P., Goldberg, I.G., Nakao, M., Saitoh, N., Harata, M
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Journal Title
BBRC
Volume: 464
Issue: 2
Pages: 554-560
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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