| Project/Area Number |
15K15072
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 光刺激 / 光応答 / 心筋細胞 / 興奮性 / アゾ化合物 / 光感受性 / 光制御 / 細胞膜 |
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| Outline of Final Research Achievements |
We conducted a study to control the activities of cells of several organisms, such as exciting cardiomyocytes, by light irradiation with simple photo-sensitive molecules. When the photosensitizing substance was present in the extracellular liquid phase, electron-microscopic observation showed that the cell membrane structure reversibly changed depending on the wavelength of the irradiated ligh. It is suggested that such changes of the cellular activities are modifying by changing property of the membrane by irraidiating light. One of the application of the system, micron-scaled power source for microactuators and so one will be realized.
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