| Project/Area Number |
15K15073
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HORIE Kuniko (INOUE Kuniko) 埼玉医科大学, 医学部, 教授 (90261982)
INOUE Satoshi 埼玉医科大学, 医学部, 客員教授 (40251251)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | ミトコンドリア / 呼吸鎖 / 超複合体 / 遺伝子改変マウス |
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| Outline of Final Research Achievements |
Mitochondrial respiration plays an important role in cells and its dysfunction is assumed to be involved in various diseases. We reported that COX7RP promotes the assembly of mitochondrial supercomplexes; however, the regulation and function of supercomplexes remains to be elucidated. In this study, expressional and functional analyses of COX7RP and other mitochondria-related factors were investigated in terms of cellar environment.
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