Study of physiological and phatophysiological functions of mitochondria supercomplex
Project/Area Number |
15K15073
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
General medical chemistry
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Research Institution | Saitama Medical University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
HORIE Kuniko (INOUE Kuniko) 埼玉医科大学, 医学部, 教授 (90261982)
INOUE Satoshi 埼玉医科大学, 医学部, 客員教授 (40251251)
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Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | ミトコンドリア / 呼吸鎖 / 超複合体 / 遺伝子改変マウス |
Outline of Final Research Achievements |
Mitochondrial respiration plays an important role in cells and its dysfunction is assumed to be involved in various diseases. We reported that COX7RP promotes the assembly of mitochondrial supercomplexes; however, the regulation and function of supercomplexes remains to be elucidated. In this study, expressional and functional analyses of COX7RP and other mitochondria-related factors were investigated in terms of cellar environment.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] A novel prognostic factor TRIM44 promotes cell proliferation and migration, and inhibits apoptosis in testicular germ cell tumor.2017
Author(s)
Yamada Y, Takayama KI, Fujimura T, Ashikari D, Obinata D, Takahashi S, Ikeda K, Kakutani S, Urano T, Fukuhara H, Homma Y, Inoue S.
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Journal Title
Cancer Sci.
Volume: 108
Issue: 1
Pages: 32-41
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] ABHD2, an androgen target gene, promotes prostate cancer cell proliferation and migration.2016
Author(s)
Obinata D, Takada S, Takayama K, Urano T, Ito A, Ashikari D, Fujiwara K, Yamada Y, Murata T, Kumagai J, Fujimura T, Ikeda K, Horie-Inoue K, Homma Y
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Journal Title
Eur J Cancer 57
Volume: 57
Pages: 39-49
DOI
Related Report
Peer Reviewed
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[Journal Article] miR-378a-3p modulates tamoxifen sensitivity in breast cancer MCF-7 cells through targeting GOLT1A2015
Author(s)
Ikeda K, Horie-Inoue K, Ueno T, Suzuki T, Sato W, Shigekawa T, Osaki A, Saeki T, Berezikov E, Mano H, Inoue S
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Journal Title
Sci Rep
Volume: 5
Issue: 1
Pages: 13170-13170
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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