| Project/Area Number |
15K15102
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | National Center for Child Health and Development |
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Principal Investigator |
HARA MARIKO 国立研究開発法人国立成育医療研究センター, 細胞医療研究部, (非)研究員 (20727424)
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| Co-Investigator(Kenkyū-buntansha) |
梅澤 明弘 国立研究開発法人国立成育医療研究センター, 再生医療センター, 副所長/再生医療センター長 (70213486)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE MAYU 国立研究開発法人 国立成育医療研究センター, 細胞医療研究部, 研究員 (40596920)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 骨・関節・筋肉・皮膚 / 子宮頸がん / パピローマ / 感染 / ワクチン / ヒトパピローマウイルス / 細胞寿命 / 遺伝子導入 / 細胞リソース / 骨 / 関節 / 筋肉 / 皮膚 / 感覚器 / 再生医療 / バイオリソース |
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| Outline of Final Research Achievements |
In regenerative medicine using human somatic cells, it is difficult to obtain a sufficient number of cells. This study has clarified the mechanism of cell life prolongation by using mesenchymal stem cells derived from various tissues and established the foundation of elemental technology for securing cells to be used for regenerative medicine. For clinical application, we established a method of cell proliferation proliferation by gene introduction method without cell damage, and developed a method to prolong cell life as normal. In addition, we have developed a means to prolong life span and terminal differentiation to the target tissue for multipotent human-derived mesenchymal stem cells (bone marrow, umbilical cord blood, menstrual blood, peripheral blood, etc.).
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