| Project/Area Number |
15K15105
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Akihiro Ishizu 北海道大学, 保健科学研究院, 教授 (60321957)
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| Co-Investigator(Kenkyū-buntansha) |
外丸 詩野 北海道大学, 医学研究科, 准教授 (20360901)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 糖尿病血管障害 / 微小炎症 / 好中球細胞外トラップ / MPO-DNA複合体 / ポリオール経路 / アルドース還元酵素阻害剤 |
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| Outline of Final Research Achievements |
Recent studies have demonstrated that high-dose glucose induces neutrophil extracellular trap (NET) formation which can be a risk for microvascular disorders. Thus, we attempted to determine the correlation of circulating NET levels and clinical/laboratory parameters in well-controlled T2D patients and to reveal the mechanism of NET formation induced by high-dose glucose. As a result, serum MPO-DNA complex levels that represent the NET formation in vivo were significantly higher in some well-controlled T2D patients in correlation with the clinical/laboratory parameters, which have been regarded as risk markers for microvascular complications. The aldose reductase inhibitor, ranirestat, could inhibit the NET formation induced by high-dose glucose. These findings suggest that elevated levels of circulating NETs can be a risk marker for microvascular complications in well-controlled T2D patients, and that the polyol pathway is involved in the NET formation induced by high-dose glucose.
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