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Energy storing mechanism in Plasmodium falciparum gametocytes

Research Project

Project/Area Number 15K15119
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Parasitology (including sanitary zoology)
Research InstitutionThe University of Tokyo

Principal Investigator

Tokumasu Fuyuki  東京大学, 大学院医学系研究科(医学部), 特任准教授 (60733475)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsマラリア / 脂質代謝 / 脂質膜 / エネルギー再利用 / 赤血球 / ガメトサイト / リサイクリング / エネルギー代謝 / 糖新生 / リン脂質 / 中性脂質 / グリセロール
Outline of Final Research Achievements

In this project, we found that (1)Plasmodium falciparum (a malaria parasite) stores lipids, membranes and neutral lipids in cytoplasm as an energy source, (2) fractions of long unsaturated fatty acids increased, and (3) unsaturated fatty acid supplemented to the culture media facilitated gametocytegenesis. In addition, glycerol, that is a metabolite of neutral lipids, added to the culture media was used as a glycerol back-born of phospholipids, indicating that glycerol is 're-cycled' for phospholipid synthesis.

These data suggest that P. falciapurm adapts to mostquito environment with low nutrients and temperature by adjusting fatty acid species and recycling stored lipids. These finding could be applied to future research to discover a candidate for transmission blocking agent.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2017 2016 2015 Other

All Int'l Joint Research (1 results) Presentation (9 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Remarks (1 results)

  • [Int'l Joint Research] National Insitutes of Health/Natl. Inst. of Standards and Technology(米国)

    • Related Report
      2016 Annual Research Report
  • [Presentation] Incorporation of Extracellular Glycerol into Phospholipids by <I>Plasmodium falciparum was Associated with a Higher Parasite Growth Rate2017

    • Author(s)
      徳舛富由樹、徳岡涼美、浜野文三江、田中健Q、エマニュエルバログン、稲岡ダニエル健、河津 信一郎、北潔、清水孝雄
    • Organizer
      第86回日本寄生虫学会大会
    • Place of Presentation
      北海道大学 学術交流会館、札幌市、北海道
    • Year and Date
      2017-05-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 熱帯熱マラリア原虫による細胞外Glycerolのリン脂質生成への取り込み2016

    • Author(s)
      徳舛富由樹, 徳岡涼美, 田中健Q, 稲岡健ダニエル, 浜野文三江, 河津信一郎, 北潔, 清水孝雄
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター・東北大学川内北キャンパス、仙台市、宮城県
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Critical roles of extracellular phospholipids in sexual differentiation of Plasmodium falciparum2016

    • Author(s)
      Takeshi Q Tanaka, Suzumi M. Tokuoka, Daichi Nakatani, Fumie Hamano, Thomas E. Wellems, Shin-ichiro Kawazu, Kiyoshi Kita, Takao Shimizu, Fuyuki Tokumasu
    • Organizer
      第15回あわじしま感染症・免疫フォーラム(The 16th Awaji International Forum on Infection and Immunity)
    • Place of Presentation
      淡路夢舞台国際会議場、淡路市、兵庫県
    • Year and Date
      2016-09-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マラリア原虫による ホスト赤血球膜改変と3 次元的環境構築2016

    • Author(s)
      徳舛富由樹
    • Organizer
      第58 回 日本脂質生化学会大会ランチョンセミナー
    • Place of Presentation
      秋田市にぎわい交流館AU(2F 展示ホール)
    • Year and Date
      2016-06-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 熱帯マラリア原虫ガメトサイト内リン脂質・中性脂質プロファイルの解析2016

    • Author(s)
      田中健Q、徳岡涼美、中谷大地、浜野文三江、河津信一郎、北潔、清水孝雄 徳舛富由樹
    • Organizer
      日本寄生虫学会
    • Place of Presentation
      宮崎市民プラザ
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report
  • [Presentation] マラリア原虫が行うホスト膜改変と3次元的環境構築2016

    • Author(s)
      徳舛富由樹
    • Organizer
      愛媛大学プロテオサイエンスセンター第3回学術シンポジウム
    • Place of Presentation
      愛媛大学南加記念ホール
    • Year and Date
      2016-02-13
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] New phase of lipid research in Plasmodium falciparum2016

    • Author(s)
      Fuyuki Tokumasu
    • Organizer
      (日米医学協力会議)U.S.-Japan Cooperative Medical Sciences Program (USJCMSP)
    • Place of Presentation
      Bethesda North Marriott Hotel and Conference Center
    • Year and Date
      2016-01-11
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 熱帯熱マラリア原虫ガメトサイトの脂質分子プロファイルの解析2015

    • Author(s)
      田中健Q、徳岡涼美、中谷大地、浜野文三江、河津信一郎、北潔、清水孝雄 徳舛富由樹
    • Organizer
      日本生化学会大会(BMB2015)
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 熱帯熱マラリア原虫ガメトサイトの脂質プロファイルの解析2015

    • Author(s)
      田中健Q、徳岡涼美、中谷大地、浜野文三江、河津信一郎、北潔、清水孝雄 徳舛富由樹
    • Organizer
      第23回分子寄生虫学ワークショップ/ 第13回分子寄生虫・マラリア研究フォーラム合同大会
    • Place of Presentation
      帯広畜産大学原虫病研究センター
    • Year and Date
      2015-08-31
    • Related Report
      2015 Research-status Report
  • [Remarks] マラリア原虫のタンパク質輸送機構に関連する脂質代謝の解明(徳舛富由樹・挑戦的萌芽研究)

    • URL

      http://lipidomics.m.u-tokyo.ac.jp/research.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2022-02-16  

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