| Project/Area Number |
15K15121
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
伊従 光洋 金沢大学, 薬学系, 准教授 (20608351)
都野 展子 金沢大学, 自然システム学系, 准教授 (60295102)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | マラリア / ハマダラカ / 唾液タンパク質 / ワクチン / 唾液 |
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| Outline of Final Research Achievements |
People living in a malaria endemic area cannot induce either protective immunity against malaria infection or inhibitory immunity against mosquito behavior following mosquito blood feeding. We hypothesize that (1) allergens containing saliva components disrupt and/or weaken host immune system, (2) functional domains of saliva proteins are hidden from host immune attack, resulting in induction of antibodies to non-functional domains of those proteins. We aim to develop a new concept malaria vaccine based on the hypothesis. The vaccine consisting of mosquito saliva proteins will overcome those allergy and decoy.
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