| Project/Area Number |
15K15145
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
TAHARA MAINO 国立感染症研究所, ウイルス第三部, 主任研究官 (10572109)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 麻疹ウイルス / ウイルスベクター / 遺伝子治療 / 再生医療 / 光遺伝学 |
|---|
| Outline of Final Research Achievements |
Measles virus (MeV) vector can transfer multiple genes into human cells efficiently without affecting the host genome. We recently have developed novel MeV gene transfer vector which is non-transmissible, can transfer multiple genes simultaneously. We could successfully generate induced pluripotent stem cells from human fibroblasts or peripheral blood T cells using this vector.
Although MeV as gene transfer vector is clearly beneficial, no method has been developed to control viral growth. We set out to design a method of controlling viral growth. Now, we developed optically controllable MeV. We believe our new optically controllable MeV vector has the potential to revolutionize gene transfer technologies.
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