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Development of oncolytic virotherapy against both cancer cells and cancer-associated fibroblasts

Research Project

Project/Area Number 15K15183
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied pharmacology
Research InstitutionOsaka University

Principal Investigator

SAKURAI FUMINORI  大阪大学, 大学院薬学研究科, 准教授 (70370939)

Co-Investigator(Renkei-kenkyūsha) FUJIWARA TOSHIYOSHI  岡山大学, 大学院医歯薬学総合研究科, 教授 (00304303)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords腫瘍溶解性ウイルス / 癌関連線維芽細胞 / アポトーシス / ネクロプトーシス / 腫瘍 / TGF-b
Outline of Final Research Achievements

Cancer-associted fibroblasts (CAF) are an important target for cancer therapy because CAF are involved in growth, survival, and mallignant alteration of cancer cells. In this study, we examined whether reovirus kills CAF. Reovirus reduced the viabilities of mouse CAF isolated from subcataneous tumors to 50-60%, indicating that reovirus mediates cell killing effects on mouse CAF. On the other hand, viabilities of normal mouse CAF were not significantly altered by reovirus. In addition, apoptotic CAF were detected in the tumor following intravenous administration of reovirus.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016 2015

All Presentation (9 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] 腫瘍溶解性ウイルスであるレオウイルスの癌関連線維芽細胞における細胞死誘導メカニズムに関する検討2018

    • Author(s)
      栗栖望、上撫忠孝、水口裕之、櫻井文教
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ウイルスを基盤とした遺伝子治療薬の臨床開発の現状と今後の展望2018

    • Author(s)
      櫻井文教
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] レオウイルスの癌関連線維芽細胞に対する殺細胞効果に関する検討2017

    • Author(s)
      栗栖望、上撫忠孝、水口裕之、櫻井文教
    • Organizer
      遺伝子デリバリー研究会第17回シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Reovirus-mediated Efficient Killing of Cancer-associated Fibroblasts2016

    • Author(s)
      Sakurai F, Kaminade T, Tachibana M, Mizuguchi H
    • Organizer
      24th Annual Congress European Society of Gene and Celll Therapy
    • Place of Presentation
      フィレンツェ、イタリア
    • Year and Date
      2016-10-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] レオウイルスを用いたマウス由来癌関連線維芽細胞に対する殺細胞効果2016

    • Author(s)
      上撫忠孝、片山由貴、宝谷拓磨、根来亮介、立花雅史、水口裕之、櫻井文教
    • Organizer
      日本薬学会第66回近畿支部大会
    • Place of Presentation
      大阪
    • Year and Date
      2016-10-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Reovirus-mediated Efficient Killing of Mouse Cancer-associated Fibroblasts2016

    • Author(s)
      Sakurai F, Kaminade T, Tachibana M, Mizuguchi H
    • Organizer
      The 22nd Annual Meeting of JSGCT
    • Place of Presentation
      東京
    • Year and Date
      2016-07-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 腫瘍溶解性ウイルスであるレオウイルスの担癌マウス由来癌関連線維芽細胞に対する殺細胞効果に関する検討2016

    • Author(s)
      上撫忠孝、立花雅史、水口裕之、櫻井文教
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Reovirus-mediated lysis of cancer-associated fibroblasts.2015

    • Author(s)
      Kaminade T, Tachibana M, Mizuguchi H, Sakurai F.
    • Organizer
      第74階日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Reovirus-mediated lysis of cancer-associated fibroblasts.2015

    • Author(s)
      Kaminade T, Sakurai F, Tachibana M, Mizuguchi H.
    • Organizer
      The 21th Annual meeting of Japan Society of Gene Therapy
    • Place of Presentation
      大阪
    • Year and Date
      2015-07-24
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 線維化を治療するための医薬組成物2016

    • Inventor(s)
      櫻井文教、水口裕之
    • Industrial Property Rights Holder
      櫻井文教、水口裕之
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-027202
    • Filing Date
      2016-02-18
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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