• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

New mechanisms of neuropathic pain after spinal cord injury

Research Project

Project/Area Number 15K15205
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pain science
Research InstitutionHyogo Medical University

Principal Investigator

Noguchi Koichi  兵庫医科大学, 医学部, 教授 (10212127)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords神経傷害性疼痛 / 脊髄損傷 / Ca チャネル / アロディニア / α2δ-1サブユニット / 疼痛 / α2δ-1
Outline of Final Research Achievements

We found the following findings using a rat model of thoracic spinal cord injury to examine the role of Ca channel subunitα2δ1 on the mechanical allodynia in the plantar surface. 1.Rat model of spinal cord injury at Th10 level showed the significant decrease in the threshold of mechanical stimuli to the plantar surface, which continued from 14-28d after spinal cord injury. 2.At 28d after SCI, theα2δ1 immunoreactivity in the lumbar spinal cord increased significantly. 3.α2δ1 mRNA in lumbar DRG showed no change after SCI, however in situ hybridization histochemistry revealed the increase in α2δ1 mRNA in superficial laminae of lumbar dorsal horn. 4. Oral administration of pregabalin (α2δ1 ligand) significantly reversed the decrease in the threshold of mechanical stimuli and also the upregulation ofα2δ1 protein in lumbar dorsal horn. The significance of the changes inα2δ1 in lumbar dorsal horn after thoracic SCI has been discussed.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (21 results)

All 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 7 results,  Open Access: 5 results,  Acknowledgement Compliant: 3 results) Presentation (14 results) (of which Int'l Joint Research: 8 results,  Invited: 3 results)

  • [Journal Article] Elevated H2 O2 levels in TNBS-induced colitis rats contributes to visceral hyperalgesia through interaction with the TRPA1 cation channel.2016

    • Author(s)
      Kogure Y, Wang S, Tanaka KI, Hao Y, Yamamoto S, Nishiyama N, Noguchi K, Dai Y.
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 未定 Issue: 6 Pages: 1147-1153

    • DOI

      10.1111/jgh.13226

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Macrophage-Colony Stimulating Factor Derived from Injured Primary Afferent Induces Proliferation of Spinal Microglia and Neuropathic Pain in Rats2016

    • Author(s)
      Masamichi Okubo, Hiroki Yamanaka, Kimiko Kobayashi, Yi Dai, Hirosato Kanda, Hideshi Yagi and Koichi Noguchi
    • Journal Title

      Plos ONE

      Volume: 11 Issue: 4 Pages: e0153375-e0153375

    • DOI

      10.1371/journal.pone.0153375

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Partial Activation and Inhibition of TRPV1 Channels by Evodiamine and Rutaecarpine, Two Major Components of the Fruits of Evodia rutaecarpa.2016

    • Author(s)
      Wang S, Yamamoto S, Kogure Y, Zhang W, Noguchi K, Dai Y
    • Journal Title

      J Nat Prod.

      Volume: 79 Issue: 5 Pages: 1225-1230

    • DOI

      10.1021/acs.jnatprod.5b00599

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Fibromyalgia and Chronic Pain Syndromes: A White Paper Detailing Current Challenges in the Field.2016

    • Author(s)
      Arnold LM, Choy E, Clauw DJ, Goldenberg DL, Harris RE, Helfenstein M Jr, Jensen TS, Noguchi K, Silverman SL, Ushida T, Wang G.
    • Journal Title

      Clin J Pain

      Volume: 32 Issue: 9 Pages: 737-746

    • DOI

      10.1097/ajp.0000000000000354

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Annexin A2 in primary afferents contributes to neuropathic pain associated with tissue type plasminogen activator2016

    • Author(s)
      Yamanaka H, Kobayashi K, Okubo M, Noguchi K
    • Journal Title

      Neuroscience

      Volume: 314 Pages: 189-199

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evodiamine suppresses capsaicin-induced thermal hyperalgesia through activation and subsequent desensitization of the transient receptor potential V1 channels.2016

    • Author(s)
      Iwaoka E, Wang S, Matsuyoshi N, Kogure Y, Aoki S, Yamamoto S, Noguchi K, Dai Y.
    • Journal Title

      J Nat Med

      Volume: 70 Issue: 1 Pages: 1-7

    • DOI

      10.1007/s11418-015-0929-1

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Leukotriene enhances NMDA-induced inward currents in dorsal horn neurons of the rat spinal cord after peripheral nerve injury2015

    • Author(s)
      Kiyoyuki Y, Taniguchi W, Okubo M, Yamanaka H, Kobayashi K, Nishio N, Nakatsuka T, Noguchi K
    • Journal Title

      Mol. Pain

      Volume: 11 Pages: 53-53

    • DOI

      10.1186/s12990-015-0059-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Activation of spinal STAT6 signaling in M2 like microglia suppressed neuropathic pain.2016

    • Author(s)
      Okutani Hiroai, Yamanaka Hiroki, Kobayashi Kimiko, Okubo Masamichi, Hirose Munetaka, Noguchi Koichi.
    • Organizer
      The 46th Annual Meeting of the Society for Neuroscience (Neuroscience 2016)
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modulation of TRPA1 activation by APM activated protein kinase.2016

    • Author(s)
      Wang Shenglan, Kobayashi Kimiko, Yamanaka Hiroki, Yamamoto Satoshi, Kogure Yoko, Noguchi Koichi, Dai Yi.
    • Organizer
      The 46th Annual Meeting of the Society for Neuroscience (Neuroscience 2016)
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microglial signaling pathways for microglial structural changes and neuropathic pain after nerve injury.2016

    • Author(s)
      Noguchi Koichi.
    • Organizer
      16th World Congerss on Pain
    • Place of Presentation
      パシフィコ横浜(神奈川・横浜市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRPA1 is Involved in Vincristine Induced Cold Allodynia.2016

    • Author(s)
      Wang Shenglan, Kojima Y, Kogure Yoko, Yamamoto Satoshi, Noguchi Koichi, Dai Yi.
    • Organizer
      16th World Congerss on Pain
    • Place of Presentation
      パシフィコ横浜(神奈川・横浜市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression of the PGE2 synthases and receptors in spinal cord following peripheral nerve injury.2016

    • Author(s)
      Kobayashi Kimiko, Kanda Hirosato, Yamanaka Hiroki, Okubo Masamichi, Noguchi Koichi.
    • Organizer
      16th World Congerss on Pain
    • Place of Presentation
      パシフィコ横浜(神奈川・横浜市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Macrophage-colony stimulating factor derived from injured primary afferent induces proliferation of spinal microglia and neuropathic pain in rats.2016

    • Author(s)
      Okubo Masamichi, Yamanaka Hiroki, Kobayashi Kimiko, Dai Yi, Kanda Hirosato, Yagi Hideshi, Noguchi Koichi.
    • Organizer
      16th World Congerss on Pain
    • Place of Presentation
      パシフィコ横浜(神奈川・横浜市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Annexin A2 in primary afferents contributes to neuropathic pain associated with tissue type plasminogen activator.2016

    • Author(s)
      Yamanaka Hiroki, Kobayashi Kimiko, Okubo Masamichi, Noguchi Koichi.
    • Organizer
      16th World Congerss on Pain
    • Place of Presentation
      パシフィコ横浜(神奈川・横浜市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression of anti-inflamatory cytokine interleukin-4 and its receptor in dorsal horn of neuropathic pain model rats.2016

    • Author(s)
      Okutani Hiroai, Kobayashi Kimiko, Yamanaka Hiroki, Okubo Masamichi, Hirose Munetaka, Noguchi Koichi.
    • Organizer
      16th World Congerss on Pain
    • Place of Presentation
      パシフィコ横浜(神奈川・横浜市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 痛みメカニズムと国際疼痛学会横浜大会について.2016

    • Author(s)
      野口 光一.
    • Organizer
      第38回日本疼痛学会
    • Place of Presentation
      北海道立道民活動センター(北海道・札幌市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 神経障害性疼痛モデルラットの脊髄後角におけるIL-4およびIL-4受容体の発現変化2016

    • Author(s)
      奥谷 博愛, 小林 希実子, 山中 博樹, 大久保 正道, 廣瀬 宗孝, 野口 光一.
    • Organizer
      第38回日本疼痛学会
    • Place of Presentation
      北海道立道民活動センター(北海道・札幌市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 末梢神経損傷後のラット脊髄におけるPGE2合成酵素とEP受容体の発現変化2016

    • Author(s)
      小林 希実子, 神田 浩里, 山中 博樹, 大久保 正道, 野口 光一.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川・横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 神経障害性疼痛の分子メカニズム2015

    • Author(s)
      野口 光一
    • Organizer
      第68回日本自律神経学会総会
    • Place of Presentation
      ウィンクあいち(愛知県名古屋市)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 神経障害性疼痛の分子メカニズム2015

    • Author(s)
      野口 光一
    • Organizer
      第44回脊椎外科を学ぶ会
    • Place of Presentation
      ツイン21МIDタワー(大阪府大阪市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 末梢神経損傷後の脊髄におけるPGE2合成酵素とEP受容体の発現変化2015

    • Author(s)
      神田 浩里, 小林 希実子, 山中 博樹, 大久保 正道, 野口 光一
    • Organizer
      第37回日本疼痛学会
    • Place of Presentation
      市民会館崇城大学ホール(熊本県熊本市)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi