New mechanisms of neuropathic pain after spinal cord injury
Project/Area Number |
15K15205
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Pain science
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Research Institution | Hyogo Medical University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 神経傷害性疼痛 / 脊髄損傷 / Ca チャネル / アロディニア / α2δ-1サブユニット / 疼痛 / α2δ-1 |
Outline of Final Research Achievements |
We found the following findings using a rat model of thoracic spinal cord injury to examine the role of Ca channel subunitα2δ1 on the mechanical allodynia in the plantar surface. 1.Rat model of spinal cord injury at Th10 level showed the significant decrease in the threshold of mechanical stimuli to the plantar surface, which continued from 14-28d after spinal cord injury. 2.At 28d after SCI, theα2δ1 immunoreactivity in the lumbar spinal cord increased significantly. 3.α2δ1 mRNA in lumbar DRG showed no change after SCI, however in situ hybridization histochemistry revealed the increase in α2δ1 mRNA in superficial laminae of lumbar dorsal horn. 4. Oral administration of pregabalin (α2δ1 ligand) significantly reversed the decrease in the threshold of mechanical stimuli and also the upregulation ofα2δ1 protein in lumbar dorsal horn. The significance of the changes inα2δ1 in lumbar dorsal horn after thoracic SCI has been discussed.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Fibromyalgia and Chronic Pain Syndromes: A White Paper Detailing Current Challenges in the Field.2016
Author(s)
Arnold LM, Choy E, Clauw DJ, Goldenberg DL, Harris RE, Helfenstein M Jr, Jensen TS, Noguchi K, Silverman SL, Ushida T, Wang G.
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Journal Title
Clin J Pain
Volume: 32
Issue: 9
Pages: 737-746
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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